微环境中巨噬细胞影响血吸虫肝纤维化的研究进展  

Advances in research on the effect of the macrophage microenvironment on liver fibrosis due to schistosomiasis

作　　者：陈聪 沈文涛 刘彦 CHEN Cong;SHEN Wen-tao;LIU Yan(Department of Medical Immunology,Institute of Pathogen Biology,University of South China,Hengyang,Hunan,China 421001;Huilong Town Health Center,Tuan Feng County)

机构地区：[1]南华大学衡阳医学院病原生物学研究所人体寄生虫学教研室,湖南衡阳421001 [2]湖南省黄州市团风县回龙山镇卫生院

出　　处：《中国病原生物学杂志》2020年第2期241-245,共5页Journal of Pathogen Biology

基　　金：湖南省自然科学基金项目(No.2019JJ40250)。

摘　　要：血吸虫性肝纤维化是一种由血吸虫虫卵在肝脏中沉积引起的慢性免疫性疾病。因其感染症状的非特异性,常易被忽视而导致发生肝脾肿大、肉芽肿、门静脉高压和肝纤维化。临床上主要是通过药物吡喹酮杀死成虫,尚无有效针对肝纤维化的防治策略。研究发现,巨噬细胞极化在血吸虫性肝纤维化发展进程中发挥着重要作用,但其机制尚不明晰。本文通过综述巨噬细胞在肝纤维化中的研究进展,为血吸虫性肝纤维化的机制研究提供新的思路和方向。Schistosomiasis hepatic fibrosis,a chronic immune disease,is caused by the deposition of Schistosoma eggs in the liver.Once schistosomiasis develops,it is often neglected because of the non-specificity of the initial symptoms of infection.Thus schistosomiasis readily leads to hepatosplenomegaly,ascites,granulomas,portal hypertension,and liver fibrosis.At present,praziquantel is the main drug used to kill mature parasites in clinical settings,but effective strategies to prevent granulomas and liver fibrosis are still lacking.Several studies have found that macrophage polarization plays an important role in the development of liver fibrosis after schistosomiasis,but the mechanism is still unclear.Thus,this article reviews advances in the study of macrophages in liver fibrosis in order to provide new insight and directions for study of the mechanism of liver fibrosis in schistosomiasis.

关 键 词：血吸虫 肝纤维化 巨噬细胞 炎性免疫 微环境 综述 

分 类 号：R383.24[医药卫生—医学寄生虫学]