雌激素对纵隔子宫电切术后宫腔纤维化的影响  

Effect of estrogen on uterine fibrosis following transcervical resection of septum

作　　者：高丽 池余刚[1] 何萍[1] 雷丽[1] 任春燕 孟莹[2] Li Gao;Yu-gang Chi;Ping He;Li Lei;Chun-yan Ren;Ying Meng(Department of Gynaecology,Chongqing Health Center for Women and Children,Chongqing 401147,China;Department of Gynaecology,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China)

机构地区：[1]重庆市妇幼保健院妇科,重庆401147 [2]重庆医科大学附属第二医院妇科,重庆400010

出　　处：《中国现代医学杂志》2020年第6期24-28,共5页China Journal of Modern Medicine

基　　金：重庆市卫计委面上项目(No.2016MSXM092)。

摘　　要：目的探讨雌激素对纵隔子宫电切术后宫腔纤维化的影响。方法选取2016年1月-2017年6月重庆市妇幼保健院收治的110例经宫腔镜检查证实后行纵隔子宫电切术的纵隔子宫患者(包括完全纵隔子宫和不完全纵隔子宫),分为实验组58例(雌激素治疗:补佳乐2 mg/次,2次/d,共21 d;最后10 d加用地屈孕酮10 mg/次,2次/d)和对照组52例(不使用雌激素治疗)。治疗1个月后再次行宫腔镜检查,评估宫腔情况,记录宫腔粘连发生情况;同时取子宫内膜组织。通过免疫组织化学染色检测转化生长因子-β(TGF-β)及结缔组织生长因子(CTGF)蛋白表达的差异,进一步通过RT-PCR检测TGF-β及CTGF mRNA的表达。结果对照组和实验组纵隔子宫电切术术后粘连发生率分别为1.9%和5.1%,差异无统计学意义(P>0.05)。两组子宫内膜组织中TGF-β及CTGF表达比较,差异无统计学意义(P>0.05)。结论雌激素不能改变纵隔子宫电切术后宫腔纤维化进程,可能是因为雌激素不能改变纤维化因子TGF-β及CTGF的表达所致。Objective To probe the effection of estrogen on uterine fibrosis following transcervical resection of septum(TCRS).Methods Totally 110 patients who underwent hysteroscopic septum resection in our hospital from January 2016 to May 2017 were allocated into two groups.In experimental group(58 patients),women received postoperative estrogen therapy,No medication was received in control group(52 patients).Further hysteroscopy was performed to assess the uterine cavity in one month later of the initial surgery.Endometrium was collected to detect the expressions of TGF-βand CTGF through immunohistochemistry and PCR.Results The postoperative adhesion rates between the two groups at one month were 1.9%(control group)and 5.1%(experimental group),respectively(P>0.05).The expression levels of TGF-βand CTGF through immunohistochemistry and PCR in endometrium were no significant difference between the two groups(P>0.05).Conclusions Estrogen cannot change the process of uterine fibrosis following TCRS,which is related to that estrogen cannot change the expressions of TGF-βand CTGF.

关 键 词：子宫疾病 组织粘连 纵隔子宫电切术 雌激素类 转化生长因子β 结缔组织生长因子 

分 类 号：R711.1[医药卫生—妇产科学]