中性粒-淋巴细胞比值与前列腺增生临床进展的相关性研究  

Correlation of neutrophil-lymphocyte ratio and the clinical progression of benign prostatic hyperplasia

作　　者：罗进阳 万瑞 姚雄波 郑嘉欣[1] 邢金春[1] 庄炫[1] Luo Jinyang;Wan Rui;Yao Xiongbo;Zheng Jiaxin;Xing Jinchun;Zhuang Xuan(Department of Urology,the First Affiliated Hospital of Xiamen University,Xiamen 361003,China;Department of Clinical Medicine,Fujian Medical University,Fuzhou 350108,China)

机构地区：[1]厦门大学附属第一医院泌尿外科,361003 [2]福建医科大学临床医学部,福州350108

出　　处：《国际泌尿系统杂志》2020年第2期250-254,共5页International Journal of Urology and Nephrology

摘　　要：目的评估中性粒-淋巴细胞比值(NLR)与前列腺增生(BPH)的相关性,并探讨NLR对BPH患者临床病程进展的影响。方法回顾性分析厦门大学附属第一医院泌尿外科在2015年1月1日至2017年12月31日收治的BPH患者274例的临床资料,采用统计学方法分析NLR与前列腺体积(PV)、国际前列腺症状评分(IPSS)、最大尿流率(Qmax)、前列腺特异性抗原(PSA)之间的相关性。按照患者的年龄、PV、IPSS、Qmax、PSA将BPH患者分为高危组和低危组,从而比较高危组和低危组之间临床进展的差异性;并运用ROC曲线分析NLR对高危组的诊断效能。继而根据术后病理是否含有炎性细胞浸润,分为无浸润组和浸润组,并在浸润组之间进行统计学分析。结果NLR与PV、IPSS均呈正相关(r=0.126,P=0.038;r=0.139,P=0.021),与Qmax呈负相关(r=-0.169,P=0.005),而与PSA无相关性(P>0.05)。根据PV及Qmax分组,高危组的NLR值高于低危组,两组之间比较差异有统计学意义(t=2.338,P=0.020;t=2.763,P=0.006);而根据年龄、IPSS及PSA分组,NLR在高危组与低危组之间比较差异无统计学意义(P>0.05)。ROC曲线分析表明,NLR作为BPH临床进展的影响因素预测PV高危组的最佳临界值为1.71,其灵敏度为71.0%,特异度为49.1%;预测Qmax高危组的最佳临界值为1.49,其灵敏度为79.4%,特异度为30.3%。浸润组的NLR值高于无浸润组,两组之间比较差异有统计学意义(t=2.156,P=0.032),且浸润组组间的比较也是有统计学意义(F=9.959,P<0.001)。结论NLR与BPH患者临床病程进展呈正相关性,是BPH临床进展的重要因素之一,可以提供患者的严重信息,并可作为患者随访的指标之一。Objective To evaluate the relationship between neutrophil-lymphocyte ratio(NLR)and benign prostatic hyperplasia(BPH),and to explore the effect of NLR on clinical progression in patients with BPH.Methods A retrospective analysis of clinical data of 274 patients with BPH who admitted to the department of urology,the first affiliated hospital of Xiamen university from January 1,2015 to December 31,2017 was performed.Statistical methods were used to analyze the correlation between NLR and prostate volume(PV),international prostate symptom score(IPSS),maximum urinary flow rate(Qmax),and prostate-specific antigen(PSA).According to age,PV,IPSS,Qmax,PSA,the patients were divided into high-risk group and low-risk group,and NLR was compared between these groups.The receiver operating characteristic(ROC)curve was used to analyze the capability of NLR in identifying patients at a high-risk of progression.Then,according to whether the postoperative pathology contains inflammatory cell infiltration,it was divided into non-invasion group and infiltration group,and statistical analysis was performed between the infiltration group.Results NLR was positively correlated with PV and IPSS(r=0.126,P=0.038;r=0.139,P=0.021),and negatively correlated with Qmax(r=-0.169,P=0.005),but not correlated with PSA(P>0.05).When the patients were divided into group based on PV and Qmax,the high-risk group had a significantly higher NLR than the low-risk group(t=2.338,P=0.020;t=2.763,P=0.006).When the patients were divided into group based on age,IPSS and PSA,there was no significant difference in NLR between high-risk group and low-risk group(P>0.05).The ROC curve analysis showed that NLR had a cut-off value of 1.71,a sensitivity of 71.0%,and a specificity of 49.1%in predicting high-risk PV,while it had a cut-off value of 1.49,a sensitivity of 79.4%,and a specificity of 30.3%in predicting high-risk Qmax.The infiltration group had a significantly higher NLR than the non-invasion group(t=2.156,P=0.032),and the comparison between the infiltration grou

关 键 词：前列腺增生 中性粒细胞/淋巴细胞比值 前列腺特异抗原 

分 类 号：R6[医药卫生—外科学]