降钙素原和C-反应蛋白对颈深部感染和脓肿诊断的临床价值  

Diagnosis value of joint detection of procalcitonin and C-reactive protein in children’s deep neck infection and abscess

作　　者：张新钢 许会卿[2] 张永波 吴卓 杨一晖[1] ZHANG Xin-gang;XU Hui-qing;ZHANG Yong-bo;WU Zhuo;YANG Yi-hui(Ootorhinolaryngology,Ningbo Maternal and Children's Hospital,Ningbo,Zhejiang 315012,China)

机构地区：[1]宁波市妇女儿童医院耳鼻咽喉科,浙江宁波315012 [2]宁波市妇女儿童医院儿内科,浙江宁波315012

出　　处：《中国卫生检验杂志》2020年第2期205-207,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的探讨降钙素原(PCT)和C-反应蛋白(CRP)对颈深部感染儿童诊断及脓肿形成评估的临床价值。方法回顾性分析2011年12月-2016年12月56例颈深部感染儿童的临床资料,通过双抗夹心免疫荧光发光定量分析法、免疫比浊法分别检测和比较颈深部脓肿组与非脓肿组患者的血清PCT、CRP水平,通过ROC曲线分析,探讨PCT、CRP及联合诊断的参考意义。结果颈深部脓肿组患者入院时PCT与CRP水平明显高于非脓肿组(P<0.05);颈深部脓肿组PCT与CRP联合诊断的确定受试者工作特征曲线下面积(AUC)最大,脓肿形成预测的灵敏度、特异度可信度最高。结论PCT与CRP在颈深部感染诊断中具有重要的临床价值,特别是颈深部脓肿形成预测评估方面具有较高的敏感性及特异性。Objective To study the relationship and clinical significance of the peripheral blood procalcitonin(PCT),C-reactive protein in children’s deep neck infection and abscess.Methods A total of 56 children with deep neck infection or abscess were diagnosed and divided into deep neck abscess group and non-deep neck abscess group according to the MRI,and the concentration of peripheral blood PCT and CRP detected by immune turbidimetric test and antibody-sandwich immunoluminometric assay.Results Compared with non-deep neck abscess group,the level of serum PCT in patients with abscess increased obviously(P<0.01).The joint detection of PCT and CRP had the most significant diagnosis value in the sensitivity,specificity and AUC(area under the ROC)about deep neck abscess.Conclusion The increase of PCT and CRP has close relation to children’s deep neck infection and the occurrence of secondary abscess.The joint detection of peripheral blood PCT and CRP in children with deep neck infection can predict the occurrence of the abscess.

关 键 词：降钙素原 C-反应蛋白 颈深部感染 颈深部脓肿 儿童 

分 类 号：R446.5[医药卫生—诊断学]