肺表面活性蛋白A在肺外疾病免疫炎性反应中的作用研究进展  

Research progress of surfactant protein A-involved immune inflammatory responses in extrapulmonary diseases

作　　者：赵正[1] 杨雪(综述)[1] 赵敏(审校)[1] Zhao Zheng;Yang Xue;Zhao Min(Emergency Department,Shengjing Hospital of China Medical University,Liaoning Province,Shenyang 110001,China)

机构地区：[1]中国医科大学附属盛京医院急诊科,沈阳110001

出　　处：《疑难病杂志》2020年第4期423-427,432,共6页Chinese Journal of Difficult and Complicated Cases

基　　金：辽宁省博士科研启动基金计划项目(2019-BS-278)。

摘　　要：表面活性蛋白A(SP-A)属胶凝素家族的重要成员,也是构成肺表面活性物质的重要蛋白成分,在维持肺部组织的内环境稳态和调节机体的免疫防御方面发挥着重要的作用。近年来,越来越多的研究发现SP-A在多个肺外组织和器官中均有表达并参与免疫炎性反应。文章就SP-A的特异性结合受体、肺泡外组织分布及其在不同疾病中发挥的免疫调节作用作一综述。Objective Surfactant protein A(SP-A),a collagen-containing C-type collectin,is an important host defense protein that functions to maintain pulmonary homeostasis and regulate inflammatory responses.Although the lung appears to be the major site of synthesis,emerging evidences have suggested that SP-A protein and mRNA are widely expressed in several extrapulmonary tissues and play a potential role in extrapulmonary immunity,which is likely to be an insightful area of research.This review enumerates expression,receptors and immunological properties of SP-A outside lungs and its immunoregulatory functions in various diseases.

关 键 词：肺表面活性蛋白A 肺外疾病 免疫调节 炎性反应 

分 类 号：R392[医药卫生—免疫学]