降压药改善高血压晨峰效果与服药时间的相关性研究  

Correlation Between Effect of Antihypertensive Drugs on Morning Peak of Hypertension and Administration Time of Antihypertensive Drugs

作　　者：管士明 GUAN Shiming(East China Sanatorium Geriatrics Department,Wuxi,Jiangsu 214065,China)

机构地区：[1]华东疗养院老年病科,江苏无锡214065

出　　处：《大医生》2019年第17期164-166,共3页Doctor

摘　　要：目的探讨降压药对高血压患者晨峰现象改善作用与服药时间的相关性,为临床改善高血压晨峰提供理论依据。方法选取2014年1月至2017年12月于华东疗养院收治的高血压患者130例,患者服用药物均为苯磺酸左旋氨氯地平片和马来酸依那普利片。将患者随机分为观察组与对照组,观察组服药时间为清晨(7:00~7:30)、夜间(19:00~19:30),对照组服药时间为清晨(7:00~7:30),24 h动态监测并记录患者血压情况。结果两组治疗前后血压及晨峰水平自身对照比较差异均存在统计学意义;观察组与对照组比较,治疗后夜间平均血压及晨峰水平差异均存在统计学意义(P<0.05)。结论与单次服药比较,高血压患者不同时间分次服用降压药可以更有效的降低夜间血压和控制晨峰现象。Objective To explore the correlation between antihypertensive drugs and the improvement of morning peak phenomenon in patients with hypertension and the time of medication,and provide a theoretical basis for the clinical treatment of high blood pressure morning peak.Methods From January 2014 to December 2017,130 patients with hypertension treated with levamlodipine besylate tablets and enalapril maleate tablets in East China Sanatorium were selected.The patients were randomly divided into observation group and control group.The observation group took the morning(7:00~7:30),nighttime(19:00~19:30),and the control group took the morning(7:00~7:30),24 h dynamic monitoring and recording of patients'blood pressure.Results There were statistically significant differences in blood pressure and morning peak levels between the two groups before and after treatment.There was a statistically significant difference in mean blood pressure and morning peak levels between the two groups after treatment(P<0.05).Conclusion Compared with a single dose of medication,hypertensive patients taking antihypertensive drugs at different times can reduce nighttime blood pressure and control morning peaks more effectively.

关 键 词：高血压晨峰 服药时间 降压疗效 

分 类 号：R54[医药卫生—心血管疾病]