微小RNA-140与骨关节炎关系的研究进展  

Role of microRNA-140 in pathogenesis of osteoarthritis

作　　者：李灿锋 尤田[1] 沈彬[2] Li Canfeng;You Tian;Shen Bin(Department of Sports Medicine and Rehabilitation,Peking University Shenzhen Hospital,Shenzhen 518036,China;Department of Orthopedics,West China Hospital of Sichuan University,Chengdu 610041,China)

机构地区：[1]北京大学深圳医院运动医学与康复医学中心,深圳518036 [2]四川大学华西医院骨科,成都610041

出　　处：《中华关节外科杂志（电子版）》2020年第1期68-72,共5页Chinese Journal of Joint Surgery(Electronic Edition)

基　　金：国家自然科学基金面上项目(81974347、81672219);深圳市医学三名工程项目(SZSM201612078);广东省医学科学技术研究基金项目(A2017202);广东省自然科学基金项目(2017A030310616)。

摘　　要：骨关节炎是一种以关节软骨退变为主的退行性疾病,但其具体发病机制目前尚不清楚。微小RNA-140(miR-140)是一种在软骨细胞中特异性高表达的microRNA,为软骨细胞调控信号网络中重要的一员,参与了软骨细胞形成、增殖、分化、衰老及凋亡的调控作用。然而,由于miR-140作用的复杂性,其参与骨关节炎(OA)软骨退变的具体分子机制目前仍不明确。本文针对miR-140在软骨形成与稳态维持、软骨退变及OA早期诊断方面的作用进行综述。Osteoarthritis is a degenerative diseases mainly in articular cartilage,but its pathogenesis has not been elucidated yet.MicroRNA-140(miR-140)is a specific and high expression microRNA in cartilage,which plays an essential role in chondrogenesis,proliferation,mature,differentiation,aging as well as apoptosis.However,due to its complex role,the molecular mechanism of miR-140 in the pathogenesis of osteoarthritis is unclear yet.Thus,this article reviewed recent literatures in order to discuss the role of miR-140 in chondorgenesis,cartilage homeostasis and degeneration as well as early diagnosis of osteoarthritis.

关 键 词：微RNA 骨关节炎 软骨细胞 

分 类 号：R684.3[医药卫生—骨科学]