拉曼光谱技术在骨关节炎早期诊断中的应用进展  

The progress of Raman spectroscopy in early diagnosis of osteoarthritis

作　　者：胡林涛 张贤祚 罗正亮 尚希福 Hu Lintao;Zhang Xianzuo;Luo Zhengliang;Shang Xifu(Department of Orthopaedics,Affiliated Provincial Hospital of Anhui Medical University,Hefei 230001,China;Department of Orthopaedics,the First Affiliated Hospital of University of Science and Technology of China,Hefei 230001,China)

机构地区：[1]安徽医科大学附属省立医院骨科,合肥230001 [2]中国科学技术大学附属第一医院骨科,合肥230001

出　　处：《中华解剖与临床杂志》2020年第1期82-86,共5页Chinese Journal of Anatomy and Clinics

基　　金：安徽省自然科学基金(1808085QH242)。

摘　　要：目的总结拉曼光谱技术在骨关节炎早期诊断中的应用相关研究进展。方法以"拉曼光谱""共焦拉曼光谱""拉曼显微镜""滴液沉积""表面增强拉曼光谱""光纤拉曼光谱""拉曼光谱带""骨关节炎""软骨",以及"Raman spectroscopy""Raman microspectroscopy""confocal Raman spectroscopy""drop deposition Raman spectroscopy""surface-enhanced Raman spectroscopy""fiber-optic Raman spectroscopy""Raman bands""osteoarthritis""cartilage"等为中、英文关键词,在中国知网、万方数据库、PubMed等中英文数据库中检索2018年12月之前发表的有关拉曼光谱技术及其在骨关节炎早期诊断中应用的文献1432篇,剔除内容不符、无法获取全文、重复性研究以及存在设计缺陷的文献,最终纳入34篇文献,进行总结和分析。结果拉曼显微镜、共焦拉曼光谱、光纤拉曼光谱技术可对骨关节炎早期软骨微观改变进行评价;液滴沉积拉曼光谱法、表面增强拉曼光谱技术可为骨关节炎早期滑膜液、血液改变提供诊断依据。结论拉曼光谱技术在骨关节炎早期诊断中显示出了很好的应用前景,但其检验标准及实用性仍有待进一步研究探讨。Objective To summarize the progress of Raman spectroscopy in early diagnosis of osteoarthritis.Methods Using"拉曼光谱""共焦拉曼光谱""拉曼显微镜""滴液沉积""表面增强拉曼光谱""光纤拉曼光谱""拉曼光谱带""骨关节炎""软骨""Raman spectroscopy""Raman microspectroscopy""confocal Raman spectroscopy""drop deposition Raman spectroscopy""surface-enhanced Raman spectroscopy""fiber-optic Raman spectroscopy""Raman bands""osteoarthritis"and"cartilage"as the key words to identify the articles about Raman spectroscopy and its application in early diagnosis of osteoarthritis in CNKI,Wanfang and PubMed before December 2018.A total of 1432 literatures were searched,and 34 literatures were finally included after excluding those with inconsistent content,inaccessible full text,repetitive research and design defects.Results Raman microspectroscopy,confocal Raman spectroscopy and fiber-optic Raman spectroscopy can evaluate the microscopic changes of cartilage in the early stage of osteoarthritis.Droplet deposition Raman spectroscopy and surface-enhanced Raman spectroscopy can provide diagnostic basis for synovial fluid and blood changes in early stage of osteoarthritis.Conclusions Raman spectroscopy has shown a brilliant application prospect in the early diagnosis of osteoarthritis,but its diagnostic standard and practicability still need to be further studied.

关 键 词：骨关节炎 光谱分析 拉曼 振动光谱 拉曼效应 

分 类 号：R6[医药卫生—外科学]