合肥地区新型冠状病毒肺炎病人预后影响因素分析  

Analysis of prognostic factors of patients with Corona Virus Disease 2019 in Hefei,China

作　　者：周俊岭 段文韬 韩华 章琦 喻芳 赵玲 叶超群 张英[1] 卜晓宇 汪桂林 杨帆[3] 张绪富[2] 鞠振宇 马礼坤 ZHOU Jun-ling;HAN Hua;ZHANG Qi;YU Fang;ZHAO Ling;YE Chao-qun;ZHANG Ying;BU Xiao-yu;WANG Gui-lin;MA Li-kun;DUAN Wen-tao;ZHANG Xu-fu;YANG Fan;JU Zhen-yu(The First Affiliated Hospital of University of Science and Technology of China,Hefei 230001,China;School of Chinese Medicine,Southern Medical University,Guangzhou 510515,China;Institute of Aging and Regenerative Medicine,Jinan University,Guangzhou 510632,China)

机构地区：[1]中国科学技术大学附属第一医院,安徽省合肥市230001 [2]南方医科大学中医药学院,广东省广州市510515 [3]暨南大学衰老与再生医学研究院,广东省广州市510632

出　　处：《实用老年医学》2020年第3期225-228,共4页Practical Geriatrics

基　　金：国家自然科学基金(81870192)。

摘　　要：目的探究新型冠状病毒肺炎(COVID-19)预后与年龄、炎症之间的关系。方法收集合肥地区72例临床确诊的COVID-19病人的临床资料,检测病人血清中CRP、IL-6、降钙素原(PCT)、红细胞沉降率(ESR)水平。将确诊病例按照年龄、性别、病情轻重等进行分层分析。结果COVID-19病人中,老年重症病人及有基础疾病的病人比例显著高于其他年龄段病人,老年治愈者比例显著低于其他年龄段病人,差异均有统计学意义(P<0.05)。老年病人的IL-6、CRP水平显著高于其他年龄段病人,重症病人的IL-6、CRP水平显著高于轻症病人,差异均有统计学意义(P<0.05)。结论年龄与炎症因素可能与新型冠状病毒感染病人患病及向重症的转化相关。Objective To explore the relationship of prognosis of Corona Virus Disease 2019(COVID-19)with age and inflammation.Methods The clinical data of 72 patients with COVID-19 in Hefei were collected.The levels of serum C-reactive protein(CRP),interleukin-6(IL-6),procalcitonin(PCT),erythrocyte sedimentation rate(ESR)were measured.The data was stratified and analyzed according to age,gender and severity of the disease.Results Among the elderly patients with COVID-19,the proportion of the patients with basic diseases and severe disease was significantly higher,and the proportion of healers was significantly lower than that of other age groups(P<0.05).The levels of IL-6 and CRP in the elderly patients with COVID-19 were significantly higher than those in other age groups(P<0.05).The levels of IL-6 and CRP in the severe patients were significantly higher than those in the mild patients(P<0.05).Conclusions Age and inflammation may increase the patients’susceptibility to the new coronavirus,and also adversely affect the patients’prognosis and outcome.

关 键 词：COVID-19肺炎 白细胞介素-6 老年人 预后 

分 类 号：R563.14[医药卫生—呼吸系统]