体外冲击波疗法促进糖尿病足溃疡愈合的机制  

Mechanisms of extracorporeal shock wave therapy in promoting healing of diabetic foot ulcer

作　　者：梁礼堪 刘小刚[2] 黄建军[2] 龚飞 张景春[2] LIANG Likan;LIU Xiaogang;Huang Jianjun;GONG Fei;ZHANG Jingchun(Graduate School,Shanxi University of Chinese Medicine,Taiyuan,Shanxi 030000,P.R.China;Department of Orthopaedics,Shanxi Provincial Hospital of Traditional Chinese Medicine,Taiyuan,Shanxi 030000,P.R.China)

机构地区：[1]山西中医药大学研究生院,太原030000 [2]山西省中医院骨关节科,太原030000

出　　处：《华西医学》2020年第3期363-366,共4页West China Medical Journal

基　　金：山西省自然科学基金(201601D102063)。

摘　　要：糖尿病足溃疡是糖尿病患者致残、致死的严重慢性并发症之一,针对这一难题,近年来关于糖尿病足溃疡的辅助疗法研究增多。体外冲击波疗法是一种已获美国食品药品监督管理局批准用于糖尿病足溃疡创面的新型辅助疗法。该文就体外冲击波疗法治疗糖尿病足溃疡的作用机制进行阐述,主要包括:创面血管生成、创面组织血流灌注、神经再生、肉芽组织增生、炎症反应、抗感染、间充质干细胞和内皮祖细胞迁移和分化,旨在为体外冲击波疗法应用于临床治疗糖尿病足溃疡提供一定的理论基础。Diabetic foot ulcer is one of the severe chronic complications that lead to disability and death of diabetic patients. In order to solve this problem, adjuvant therapy studies of diabetic foot ulcers have increased in recent years. Extracorporeal shock wave therapy is a novel adjuvant therapy that has been approved by the US Food and Drug Administration for diabetic foot ulcers wounds. In this paper, the mechanisms of extracorporeal shock wave therapy for diabetic foot ulcers are described, including wound angiogenesis, wound tissue blood perfusion, nerve regeneration,granulation tissue proliferation, inflammatory response, anti-infection, migration and differentiation of mesenchymal stem cells and endothelial progenitor cells. This study aims to provide a theoretical basis for the clinical application of extracorporeal shock wave therapy in clinical treatment of diabetic foot ulcers.

关 键 词：糖尿病足溃疡 体外冲击波疗法 机制 

分 类 号：R587.2[医药卫生—内分泌]