清胃降逆方联合西医常规疗法治疗反流性食管炎肝胃郁热证临床研究  

Clinical Study on Qingwei Jiangni Prescription Combined with Western Routine Therapy in Treatment of Reflux Esophagitis with Liver-Stomach Depression-heat Syndrome

作　　者：王俊丽[1] 刘汶[2] WANG Junli;LIU Wen(Beijing Pinggu District Hospital,Beijing 101200,China;Beijing Traditional Chinese Medicine Hospital Affiliated to Capital Medical University,Beijing 100010,China)

机构地区：[1]北京市平谷区医院,北京101200 [2]首都医科大学附属北京中医医院,北京100010

出　　处：《中国中医药信息杂志》2020年第3期28-32,共5页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：北京市中医药科技发展资金(JJ2017-91)。

摘　　要：目的探讨清胃降逆方联合西医常规疗法治疗反流性食管炎(RE)肝胃郁热证临床疗效,及对患者胃肠激素指标及食管黏膜氧化应激指标的影响。方法采用随机数字表法将81例RE肝胃郁热证患者分为对照组(40例)和研究组(41例)。对照组予雷贝拉唑钠肠溶片+多潘立酮片,口服;治疗组在对照组基础上予清胃降逆方,每日1剂,每日2次,口服。2组均连续治疗4周,随访3个月。观察2组临床疗效,比较2组治疗前后中医症状评分及内镜评分、胃肠激素及食管黏膜氧化应激指标,观察不良反应及复发率。结果研究组总有效率为90.24%(37/41),对照组为72.50%(29/40),2组比较差异有统计学意义(P<0.05)。与本组治疗前比较,2组治疗后反酸、烧心、胸骨后灼痛评分及内镜评分明显降低(P<0.05);2组治疗后比较,研究组上述各项评分明显低于对照组(P<0.05)。与本组治疗前比较,2组治疗后胃泌素、胃动素、总超氧化物歧化酶水平明显升高,丙二醛、一氧化氮水平明显降低(P<0.05);2组治疗后比较,研究组胃泌素、胃动素、总超氧化物歧化酶水平明显高于对照组,丙二醛、一氧化氮水平明显低于对照组(P<0.05)。2组不良反应率比较差异无统计学意义(P>0.05),研究组复发率低于对照组(P<0.05)。结论清胃降逆方联合西医常规疗法治疗RE肝胃郁热证患者疗效显著,可改善患者中医症状评分及内镜评分,调节胃肠激素水平及食管黏膜氧化应激指标水平,安全性较高,复发率低。Objective To explore the clinical efficacy of Qingwei Jiangni Prescription combined with Western routine therapy in the treatment of reflux esophagitis(RE)with liver-stomach depression-heat syndrome,and the influence on gastrointestinal hormone index and esophageal mucosal oxidative stress index.Methods Totally 81 RE patients with liver-stomach depression-heat syndrome were divided into control group(40 cases)and study group(41 cases)according to random number table method.The control group was given rabeprazole sodium enteric-coated tablets+domperidone tablets,while the study group was given Qingwei Jiangni Prescription on the basis of the control group one dosage per day,twice a day,orally.Treatment for both groups lasted for consecutive 4 weeks,with three-month follow-up.The clinical efficacy of the two groups were compared,and the TCM symptom scores and gastroscopy score,gastrointestinal hormone index,and esophageal mucosal oxidative stress index were observed before and after treatment in the two groups.The adverse reactions and recurrence rate were observed.Results After treatment,the total effective rate was 90.24%(37/41)in the study group,and 72.50%(29/40)in the control group,with statistical significance(P<0.05).Compared with before treatment,the scores of acid reflux,heartburn,poststernal burning pain and gastroscopy in the the two groups were significantly decreased(P<0.05);After treatment,the above scores of the study group were significantly lower than those of the control group(P<0.05).Compared with before treatment,the levels of gastrin,motilin,total superoxide dismutase significantly increased,and the levels of malondialdehyde and nitric oxide were significantly reduced after treatment in the two groups(P<0.05);After treatment,the levels of gastrin,motilin,and total superoxide dismutase in the study group were significantly higher than those in the control group,and the levels of malondialdehyde and nitric oxide were significantly lower than those in the control group(P<0.05).There was no statisti

关 键 词：清胃降逆方 反流性食管炎 肝胃郁热证 胃肠激素 临床研究 

分 类 号：R259.71[医药卫生—中西医结合]