有机锡1,1′-亚甲基双(1H-吡唑-4-甲酸酯)的合成、结构与抗肿瘤活性  

Synthesis, Structure and Antitumor Activity of Organotin 1,1'-Methylenebis(1H-pyrazole-4-carboxylates)

作　　者：谢运甫[1] 唐良富[2] XIE Yun-Fu;TANG Liang-Fu(College of Science,Tianjin University of Science and Technology,Tianjin 300457,China;State Key Laboratory of Elemento-Organic Chemistry,College of Chemistry,Nankai University,Tianjin 300071,China)

机构地区：[1]天津科技大学理学院,天津300457 [2]南开大学化学学院,元素有机化学国家重点实验室,天津300071

出　　处：《无机化学学报》2020年第4期755-761,共7页Chinese Journal of Inorganic Chemistry

基　　金：天津市教委资助项目(No.20140503)。

摘　　要：通过1,1′-亚甲基双(1H-吡唑-4-甲酸)(CH2(PzCO2H)2)与R3SnOH或(R3Sn)2O的反应,合成了4个有机锡1,1′-亚甲基双(1H-吡唑-4-甲酸酯)衍生物(CH2(PzCO2SnR3)2,R=Ph(1),环己基(2),Et(3),n-Bu(4))。通过红外和核磁对这些配合物进行了详细的结构表征。配合物1和3的X射线单晶衍射分析表明,这2个配合物中的吡唑氮原子均没有参与配位,但它们的羧酸根却表现出明显不同的配位方式。配合物1中羧酸根为单齿配体,且该配合物表现为简单双核结构;配合物3中羧酸根为双齿配体,其通过羧基的桥式双齿配位方式形成具有32元大环结构单元的二维配位高分子。初步的生物活性测试表明,这些有机锡衍生物对MCF-7和A549细胞具有很好的体外细胞毒性。Four triorganotin 1,1'-methylenebis(1H-pyrazole-4-carboxylates)(CH2(PzCO2SnR3)2,R=Ph(1),cyclohexyl(2),Et(3),n-Bu(4))have been synthesized via the reaction of R3SnOH or(R3Sn)2O with 1,1'-methylenebis(1H-pyrazole-4-carboxylic acid).All these complexes were characterized by elemental analysis,IR and multinuclear NMR(1H,13C and 119Sn).The structures of 1 and 3 have been confirmed by the X-ray single crystal diffraction analysis,suggesting that the pyrazoyl nitrogen atoms don't participate in coordination to the tin atoms,and the carboxylate groups show considerably different coordination modes in these two complexes.In addition,complex 1 only shows a dinuclear structure,while complex 3 forms a 2D-coordination polymer with 32-membered macrocyclic units through the bridging carboxylate oxygen atoms.The cytotoxic activity of these complexes for MCF-7 and A549 cells was tested,showing that they displayed good cytotoxicities for these two cells in vitro.

关 键 词：氮配体 有机锡羧酸酯 晶体结构 抗肿瘤活性 

分 类 号：O614.432[理学—无机化学]