云南省玉溪市未抗病毒治疗HIV/AIDS患者T淋巴细胞计数自然变化  

Changes related to the natural CD3+,CD4+,CD8+T cell counts among antiretroviral treatment-naive HIV/AIDS patients in Yuxi,Yunnan

作　　者：朱永芬 董文斌[1] 李世福[1] 赵金仙[1] 陈黎跃[1] 蔡英[1] 鲁建波[1] 李顺祥[1] 许杰[1] 李泽 ZHU Yongfen;DONG Wenbin;LI Shifu;ZHAO Jinxian;CHEN Liyue;CAI Ying;LU Jianbo;LI Shunxiang;XU Jie;LI Ze(Yuxi Centre for Disease Control and Prevention,Yuxi,Yunnan 653100,China)

机构地区：[1]玉溪市疾病预防控制中心,云南玉溪653100

出　　处：《中国热带医学》2020年第3期263-266,共4页China Tropical Medicine

摘　　要：目的探讨玉溪市未抗病毒治疗HIV感染者/艾滋病患者(HIV/AIDS)T淋巴细胞计数(CD3、CD4和CD8)自然变化,了解其艾滋病自然病程。方法收集2006—2014年间玉溪市新报告HIV/AIDS未抗病毒治疗资料,获取首次与末次CD3、CD4和CD8数据,描述并比较CD3、CD4和CD8自然变化速率。结果CD3、CD4和CD8月均自然变化速率分别为4.14个/μL、-2.13个/μL和7.57个/μL。其中886例(62.66%)CD4末次较首次低,表现为自然下降。首次CD4越高,其月均下降越快,而首次CD4较低,其月均下降较慢甚至出现上升,差异有统计学意义(P<0.05)。男性、汉族、≥50岁者、传播途径为注射吸毒者月均CD4自然变化下降速率较快,而女性、少数民族、50岁以下者、传播途径为性传播者CD3、CD8上升速率较快,差异均有统计学意义(P均<0.05)。结论玉溪市HIV/AIDS CD3、CD4和CD8自然变化总体平缓,但仍然有部分HIV/AIDS的CD4下降较快,或是CD3、CD8上升较快,需对该类人群加强随访,及时介入抗病毒治疗。Objective To explore the HIV disease progression and the changes related to the natural CD3+,CD4+,CD8+T cell counts among antiretroviral treatment-naive HIV/AIDS patients in Yuxi prefecture.Methods The counts of CD3+,CD4+,CD8+T cell were collected with retrospective study from 2006 to 2014.Difference and change rate of CD3+,CD4+,CD8+T cell counts was calculated and described.Results The mean natural change rates of CD3,CD4 and CD8 were 4.14/μL,-2.13/μL and 7.57/μL,respectively.About 886 cases(62.66%)of the HIV/AIDS patients had deletions of CD4+T cell counts.The higher the primary CD4+T cell counts was,the faster the decline of CD4+T cell counts between the first and the last,while the lower the primary CD4+T cell counts was,the slower the decline of CD4+T cell counts between the first and the last,there were of statistical significance(P<0.05).Results from the statistical analysis indicated that male,the Han ethnicity,the people aged 50 or more,transmission mode was injecting drug using were significantly associated with the significant depletion of CD4+T cell counts,while that female,minority,the people under the age of 50,transmission mode was sex were significantly associated with the significant uptrend of CD3+,CD8+T cell counts(all of P<0.05).Conclusion The changing rate of CD3+,CD4+,CD8+T cell counts among ART-na?ve HIV infected patients in Yuxi prefecture was relatively slow.However,substantial proportion of them showed significant decreases of CD4+T cell counts,or some of them showed significant increases of CD3+,CD8+T cell counts,which was determined by many factors,consistently follow-up those HIV infected patients were needed and the initiation of ART,if necessary.

关 键 词：HIV感染者 艾滋病患者 T淋巴细胞计数 自然变化 病程进展 

分 类 号：R512.91[医药卫生—内科学]