白介素-1β 在冠心病中的研究进展  

Interleukin-1β in Coronary Heart Disease

作　　者：顾佳仪 刘正霞[2] 鲁翔[1,2] GU Jiayi;LIU Zhengxia;LU Xiang(Nanjing Medical University,Nanjing 211166,Jiangsu,China;Laboratory of Geriatrics,The Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011,Jiangsu,China)

机构地区：[1]南京医科大学,江苏南京211166 [2]南京医科大学第二附属医院老年医学实验室,江苏南京210011

出　　处：《心血管病学进展》2020年第2期125-128,共4页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金(81300999,81470501,81770440)。

摘　　要：冠状动脉粥样硬化性心脏病(冠心病)是导致全世界人群发病和死亡的主要原因。炎症通路的激活和失调参与了冠心病从最初斑块的发生、发展到最终斑块破裂的不同阶段。白介素-1β是一个经典的炎症细胞因子,大量的研究表明白介素-1β参与冠心病的发病机制。现就白介素-1β与冠心病的研究进展进行综述。Coronary heart disease is the main cause of morbidity and mortality in people all over the world.The activation and imbalance of inflammatory pathway are involved in different stages of coronary heart disease from the occurrence to the final rupture of the plaque.Interleukin-1β is a classical inflammatory cytokine.A large number of studies have shown that interleukin-1β is involved in the pathogenesis of coronary heart disease.This paper reviews the research progress of interleukin-1β and coronary heart disease.

关 键 词：冠心病 炎症 预后 白介素-1Β 

分 类 号：R541.4[医药卫生—心血管疾病]