Nrf2与心血管系统疾病的相关性研究  

Correlation Between Nrf2 and Cardiovascular Diseases

作　　者：王茂 王光英 王迪 魏玲[1,2] WANG Mao;WANG Guangying;WANG Di;WEI Ling(Kunming Medical University Graduate School,Kunming 650000,Yunnan,China;Civil Cadres'Ward,The 920th Hospital of Joint Logistics Support Force,Kunming 650032,Yunnan,China)

机构地区：[1]昆明医科大学研究生部,云南昆明650000 [2]联勤保障部队第九二○医院地方干部病房,云南昆明650032

出　　处：《心血管病学进展》2020年第2期175-178,共4页Advances in Cardiovascular Diseases

摘　　要：核因子E2相关因子2(Nrf2)属于碱性亮氨酸转录家族成员,是抵抗细胞氧化应激的重要转录因子。Nrf2参与众多病理生理过程,Nrf2及下游靶基因的激活不仅能调控细胞氧化应激,还参与炎症反应和细胞自噬的调节。研究显示,Nrf2在心血管系统疾病的发生发展中发挥着重要作用。现就Nrf2与心血管系统疾病的相关性研究做一综述。Nuclear factor E2-related factor 2(Nrf2)is a member of the basic leucine transcript family and is an important transcription factor against cellular oxidative stress.Nrf2 is involved in many pathophysiological processes.The activation of Nrf2 and downstream target genes can not only regulate cellular oxidative stress,but also participate in the regulation of inflammatory response and autophagy.Studies have shown that Nrf2 plays an important role in the development of cardiovascular diseases.This article reviews the relationship between Nrf2 and cardiovascular diseases.

关 键 词：NRF2 血管老化 心血管系统疾病 

分 类 号：R54[医药卫生—心血管疾病]