注射用鹿瓜多肽治疗脑梗死恢复期临床疗效观察  

Clinical Observation on Treatment of Cerebral Infarction at Convalescence Stage with Cervus and Cucumis Polypeptide for Injection

作　　者：张萍[1] 杜少辉[2] 李伶 单韵 郭瑞胜 ZHANG Ping;DU Shao-Hui;LI Ling;SHAN Yun;GUO RuiSheng(The Fourth Clinical Medical School of Guangzhou University of Chinese Medicine,Shenzhen 518033 Guangdong,China;Dept.of Geriatrics,Shenzhen Traditional Chinese Medicine Hospital,Shenzhen 518033 Guangdong,China)

机构地区：[1]广州中医药大学第四临床医学院,广东深圳518033 [2]深圳市中医院老年病科,广东深圳518033

出　　处：《广州中医药大学学报》2020年第3期394-398,共5页Journal of Guangzhou University of Traditional Chinese Medicine

摘　　要：【目的】观察有扶阳通督作用的中药制剂注射用鹿瓜多肽对脑梗死恢复期阳虚患者的治疗效果。【方法】将60例脑梗死恢复期阳虚患者随机分为试验组和对照组,每组各30例。对照组给予常规口服阿司匹林肠溶片、阿托伐他汀钙片治疗,试验组在对照组常规治疗的基础上加用注射用鹿瓜多肽静滴治疗,疗程为30 d。观察2组患者治疗前后美国国立卫生研究院卒中量表(NIHSS)、改良版RANKIN量表(MRS)、 Barthel指数(BI)评分的变化情况,并以NIHSS评分为基础进行疗效评定。【结果】(1)NIHSS评分疗效:治疗1个月后,试验组的总有效率为80.00%,对照组为63.33%,试验组的总体疗效优于对照组,差异有统计学意义(P<0.05)。(2)治疗后,2组患者的NIHSS评分和MRS评分均较治疗前明显降低,BI评分均较治疗前明显升高,差异均有统计学意义(P<0.01),且试验组对NIHSS评分和MRS评分的降低作用及对BI评分的升高作用均优于对照组,差异均有统计学意义(P<0.05)。【结论】注射用鹿瓜多肽联合常规治疗能明显提高脑梗死恢复期阳虚患者的恢复疗效。Objective To observe the clinical effect of Cervus and Cucumis Polypeptide for Injection,a Chinese medicine extract injection with the actions of supporting yang and regulating the Governor Vessel,for the treatment of cerebral infarction at convalescence stage with yang deficiency. Methods Sixty patients with cerebral infarction at convalescence stage with yang deficiency were randomly divided into trial group and control group,30 cases in each group. The control group was conventionally treated with aspirin enteric-coated tablets and atorvastatin calcium tablets,and the treatment group was treated with Cervus and Cucumis Polypeptide for Injection based on the treatment for the control group. The treatment for the two groups lasted 30 days. Before and after treatment,the scores of National Institutes of Health Stroke Scale(NIHSS),the modified RANKIN scale(MRS)and the Barthel Index(BI)in the two groups were compared. And the efficacy of the two groups was evaluated on the basis of the NIHSS scores. Results(1)After treatment for one month, the total effective rate in the trial groups was 80.00% and that in the control group was 63.33%,the overall efficacy in the trial group was superior to that in the control group,and the difference was statistically significant(P < 0.05).(2)After treatment,the scores of NIHSS and MRS in the two groups were markedly decreased and BI scores were obviously increased in comparison with those before treatment,the difference being statistically significant(P < 0.01). The trial group had stronger effect on decreasing the scores of NIHSS and MRS and on increasing the BI scores than the control group,the difference being statistically significant(P < 0.05). Conclusion Cervus and Cucumis Polypeptide for Injection combined with conventional western medicine treatment is effective for improving the recovery of cerebral infarction patients at convalescence stage with yang deficiency.

关 键 词：脑梗死恢复期 阳虚 注射用鹿瓜多肽 扶阳通督 

分 类 号：R277.7[医药卫生—中医学] R743.33