吕绍光从肝郁论治围绝经期非器质性失眠用药规律研究  

Study on Medication Rules of Treating Liver Depression in Perimenopausal Non-organic Insomnia by LüShaoguang

作　　者：李红[1] 谢丽君 陈莹[1] 陈婷 马坤[1] 郑姜钦[1] 陈翔[1] 吕绍光(指导)[1] LI Hong;XIE Lijun;CHEN Ying;CHEN Ting;MA Kun;ZHENG Jiangqin;CHEN Xiang;LYU Shaoguang(Provincial Clinical Medical College,Fujian Medical University,Fuzhou 350001,China;Fujian University of Chinese Medicine,Fuzhou 350122,China)

机构地区：[1]福建医科大学省立临床医学院,福建福州350001 [2]福建中医药大学,福建福州350122

出　　处：《中国中医药信息杂志》2020年第2期88-92,共5页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金(81473599);国家中医药管理局第四批全国中医(临床、基础)优秀人才研修项目(2017年);福建省医学创新课题(2016-CX-8);福建省卫生计生委青年科研课题(2016/1/6)。

摘　　要：目的总结吕绍光从肝郁论治围绝经期非器质性失眠的用药规律。方法收集经吕绍光诊治的肝郁型围绝经期非器质性失眠患者处方,采用频数分析、关联规则等统计方法,总结高频药物及四性、五味、归经、类别,挖掘常见药对和簇药(3味及以上药组成)。结果共纳入病例219例,处方219张,使用药物108味。使用频次最高的前3位药物依次为合欢皮、郁金、香附;药类频次前3位依次为理气药、补虚药、安神药;平性药使用频次最高,其次是温性药,大寒性药物使用频次为0;甘、苦、辛味药居药味总频次前3位;药物归经前3位依次为肝、心、肾经。关联规则筛选得到安神药对9对、解郁药对7对,簇药22条。结论吕绍光从肝郁论治围绝经期非器质性失眠以理气、补虚、安神药为主,用药多归肝经,药性平和,以甘、苦、辛味为主,善用解郁安神、气血双调药对。Objective To summarize the medication rules in treating perimenopausal non-organic insomnia by LüShaoguang from liver depression.Methods Prescriptions for treating patients with perimenopausal non-organic insomnia by LüShaoguang were collected.Statistical methods,such as frequency analysis and association rules were used to summarize high-frequency medicine,four properties,five tastes and categories,and common medicinal pairs and combined medicine(composed by three and more kinds of Chinese materia medica)were mined.Results Totally 219 cases,219 prescriptions and 108 kinds of Chinese materia medica were included.The top three kinds of Chinese materia medica with the highest use frequency were Albiziae Cortex,Curcumae Radix,and Cyperi Rhizoma;the top three types of medicine with the highest frequency were regulating qi medicine,tonifying deficiency medicine,and sedative tranquillizing medicine;mild property medicine was with the highest use frequency,followed by warm property medicine.The use frequency of great cold property medicine was 0.Sweet,bitter and spicy taste were the top three in the total frequency;the top three belonging meridians were liver,heart,and kidney meridians.The association rules screened and obtained 9 pairs of sedative tranquillizing medicine,7 pairs of antidepressants,and 22 items of combined medicine.Conclusion Qi regulating medicine,tonify deficiency medicine and sedative tranquillizing medicine are commonly used in treating perimenopausal non-organic insomnia by LüShaoguang,and the medication mainly belongs to liver meridian;the medicinal properties is mainly mild;sweet,bitter and pungent are given priority.LüShaoguang is expert in using medicinal pairs of antidepressants and regulating qi and blood.

关 键 词：吕绍光 肝郁 围绝经期 失眠 用药规律 

分 类 号：R2-05[医药卫生—中医学] R259.886