透明质酸修护生物膜联合氯雷他定片治疗特应性皮炎的临床效果  

Clinical effect of hyaluronic acid repair biofilm combined with Loratadine Tablets in the treatment of atopic dermatitis

作　　者：刘文芳[1] 赵子申 张海祥 IU Wenfang;ZHAO Zishen;ZHANG Haixiang(Department of Surgery,Cangzhou Medical College,Heibei Province,Cangzhou 061001,China;Department of Dermatology,Cangzhou People′s Hospital,Heibei Province,Cangzhou 061000,China)

机构地区：[1]沧州医学高等专科学校外科教研室,河北沧州061001 [2]河北省沧州市人民医院皮肤科,河北沧州061000

出　　处：《中国医药导报》2020年第8期139-143,共5页China Medical Herald

基　　金：河北省重点研发计划自筹项目(172777188)。

摘　　要：目的观察透明质酸修护生物膜联合氯雷他定片治疗特应性皮炎的临床效果以及对血清白细胞介素(IL)-2和IL-4水平的影响。方法收集2017年1月~2018年2月在沧州市人民医院就诊的特应性皮炎患者160例,按随机数字表法将其分为对照组和观察组,每组各80例。对照组给予氯雷他定片治疗(10 mg/次,1次/d)。观察组在对照组治疗基础上给予透明质酸修护生物膜涂抹护肤,早晚各1次,连续治疗4周后。比较两组患者特应性皮炎皮损评分指数(SCORAD)、视觉模拟尺度评分(VAS)、皮脂含量、角质层含水量、鳞屑中人组织激肽释放酶5(KLK5)、经皮水分丢失(TEWL)、鳞屑中不成熟角质套膜(CE)、血清IL-2、IL-4及临床疗效。结果两组患者治疗前SCORAD和VAS评分比较,差异无统计学意义(P>0.05);与治疗前比较,两组患者治疗后SCORAD和VAS评分明显降低,且观察组治疗后SCORAD和VAS评分均显著低于对照组,差异均有高度统计学意义(均P<0.01)。两组患者治疗前皮脂含量、角质层含水量、鳞屑中KLK5、TEWL、鳞屑中不成熟CE比例比较,差异无统计学意义(P>0.05)。与治疗前比较,两组患者治疗后皮脂含量、角质层含水量、鳞屑中KLK5明显升高,TEWL、鳞屑中不成熟CE比例显著减少,且观察组患者治疗后皮脂含量、角质层含水量、鳞屑中KLK5明显高于对照组,TEWL、鳞屑中不成熟CE比例显著低于对照组,差异均有高度统计学意义(均P<0.01)。两组患者治疗前血清IL-2和IL-4水平比较,差异无统计学意义(P>0.05)。与治疗前比较,两组患者治疗后血清IL-2水平明显升高,IL-4水平显著减少,且观察组治疗后血清IL-2水平显著高于对照组,IL-4水平显著低于对照组,差异均有高度统计学意义(均P<0.01)。观察组总有效率高于对照组,差异有统计学意义(P<0.05)。结论透明质酸修护生物膜联合氯雷他定片可明显改善特应性皮炎患者的临床症状、皮肤屏障功�Objective To observe the clinical effect of hyaluronic acid repair biofilm combined with Loratadine Tablets in the treatment of atopic dermatitis and the effect on serum interleukin(IL)-2 and IL-4 levels.Methods One hundred and sixty patients with atopic dermatitis who were admitted to Cangzhou People′s Hospital from January 2017 to February 2018 were collected and divided into the control group and the observation group according to the random number table method,with 80 cases in each group.The control group was treated with Loratadine Tablets(10 mg/time,1 time/d).The observation group was given hyaluronic acid repair biofilm for skin care on the basis of treatment of the control group,once in the morning and once in the evening,after 4 weeks of continuous treatment.Scoring atopic dermatitis index(SCORAD),visual analogue scale(VAS),sebum content,cuticle water content,scale human tissue kallikelin 5(KLK5),transepidermal water loss(TEWL),immature cornified envelope in scales(CE),serum IL-2,IL-4 and clinical efficacy were compared between the two groups.Results There was no significant difference in SCORAD and VAS scores before treatment between the two groups(P>0.05).Compared with before treatment,the SCORAD and VAS scores of the two groups were significantly decreased after treatment,and the SCORAD and VAS scores in the observation group were significantly lower than that in the control group,the differences were highly statistically significant(all P<0.01).There was no significant difference in sebum content,cuticle water content,KLK5 in scales,TEWL and immature CE ratio in scales between the two groups before treatment(P>0.05).Compared with before treatment,sebum content,cuticle water content and KLK5 in scales in the two groups were significantly increased after treatment,while the proportion of TEWL and immature CE in scales was significantly reduced,and the sebum content,cuticle water content and KLK5 in scales in the observation group were significantly higher than those in the control group,while the pro

关 键 词：透明质酸修护生物膜 氯雷他定片 特应性皮炎 细胞因子 

分 类 号：R751[医药卫生—皮肤病学与性病学]