抑郁症患者胶质细胞源性神经营养因子、Nod样受体蛋白3炎症小体表达水平及其诊断价值  

Expression level and the diagnostic value of glial cell line-derived neurotrophic factor and Nod-like receptor protein 3 inflammatory in patients with depression

作　　者：田海华 刘纪猛 徐国安 李广学 万小晗 张娇 高树贵 TIAN Haihua;LIU Jimeng;XU Guoan;LI Guangxue;WAN Xiaohan;ZHANG Jiao;GAO Shugui(Department of Clinic Laboratory,Ningbo Kangning Hospital,Zhejiang Province,Ningbo 315201,China;Department of Affective Disorder Ward,Ningbo Kangning Hospital,Zhejiang Province,Ningbo 315201,China;Ningbo university School of Medicire,Zhejiang Province,Ningbo 315211,China)

机构地区：[1]浙江省宁波市康宁医院检验科,浙江宁波315201 [2]浙江省宁波市康宁医院情感障碍科,浙江宁波315201 [3]宁波大学医学院,浙江宁波315211

出　　处：《中国医药导报》2020年第8期148-151,共4页China Medical Herald

基　　金：浙江省医药卫生科技计划项目(2019KY628)。

摘　　要：目的探究抑郁症患者胶质细胞源性神经营养因子(GDNF)、Nod样受体蛋白3(NLRP3)炎症小体表达水平变化及其诊断价值。方法选择2018年1月~2019年6月浙江省宁波市康宁医院(以下简称“我院”)情感障碍科收治的100例抑郁症患者作为抑郁症组,另选择同期在我院进行常规体检的60名健康人群作为对照组。比较两组患者以及不同严重程度的抑郁症患者GDNF表达情况及血清NLRP3炎症小体水平,分析抑郁严重程度与GDNF、血清NLRP3炎症小体水平的相关性,计算GDNF、NLRP3炎症小体单项检测以及联合检测在诊断抑郁症中的诊断效能。结果抑郁症组GDNF水平明显低于对于对照组,血清NLRP3炎症小体水平明显高于对照组,差异均有统计学意义(均P<0.05)。不同严重程度抑郁症患者的GDNF及NLRP3炎症小体水平比较,差异有统计学意义(P<0.05)。与轻度抑郁组比较,中度抑郁组、重度抑郁组GDNF水平降低、NLRP3炎症小体水平升高,差异均有统计学意义(均P<0.05),与中度抑郁组比较,重度抑郁组GDNF水平降低、NLRP3炎症小体水平升高,差异均有统计学意义(均P<0.05)。GDNF表达水平与抑郁症严重程度均呈负相关(r=-0.603,P<0.05),血清NLRP3炎症小体表达水平与抑郁症严重程度均呈正相关(r=0.762,P<0.05)。GDNF、NLRP3炎症小体联合检测诊断抑郁症的敏感度和特异度明显高于GDNF、NLRP3炎症小体单项检测,且有较好的特异度。结论GDNF及血清NLRP3炎症小体的异常表达与抑郁症的发生、发展密切相关,GDNF、NLRP3炎症小体联合检测有助于抑郁症诊断和病情评估。Objective To investigate the changes of glial cell-derived neurotrophic factor(GDNF)and nod-like receptor protein 3(NLRP3)inflammasome in major depressive disorder patients and analyze the diagnostic value.Methods A total of 100 patients with major depressive disorder admitted to the Department of Affective Disorder,Ningbo Kangning Hospital(“our hospital”for short)from January 2018 to June 2019 were selected as the depression group.A total of 60 healthy people underwent routine physical examination in our hospital during the same period were selected as the control group.The expression of serum GDNF and NLRP3 inflammasome were compared between the two groups of patients and patients with depression of different severity.The correlation between the severity of depression and the diagnostic efficacy of GDNF and NLRP3 inflammasome single test and combined test in diagnosing depression were calculated.Results The level of GDNF in the depression group was significantly lower than that of the control group,and the serum NLRP3 level of the inflamatome was significantly higher than that of the control group,with statistically significant differences(all P<0.05).The levels of GDNF and NLRP3 in patients with depression of different severity were statistically significant differences(P<0.05).Compared with the mild depression group,the GDNF level in the moderate depression group and the severe depression group were decreased and the NLRP3 inflammasome was increased,the differences were statis tically significant(all P<0.05).Compared with the moderate depression group,the GDNF level in the severe depression group were decreased and the NLRP3 inflammasome was increased,the differences were statistically significant(all P<0.05).The expression level of GDNF was negatively correlated with the severity of depression(r=-0.603,P<0.05),while the expression level of serum NLRP3 inflamosome was positively correlated with the severity of depression(r=0.762,P<0.05).The sensitivity and specificity of combined detection of GDNF and NLR

关 键 词：抑郁症 胶质细胞源性神经营养因子 Nod样受体蛋白3炎症小体 诊断价值 

分 类 号：R651.2[医药卫生—外科学]