伊布利特的电生理作用及临床应用进展  

Electrophysiological Mechanism and Clinical Application Progress of Ibutilide

作　　者：杨雅舒 宋旭东[1] 刘磊[1] 阙冬冬[1] 余文杰[1] 杨平珍[1] YANG Ya-shu;SONG Xu-dong;LIU Lei;QUE Dong-dong;YU Wen-jie;YANG Ping-zhen(Dept.of Cardiology,Zhujiang Hospital of Southern Medical University,Guangzhou Guangdong 510282,China)

机构地区：[1]南方医科大学珠江医院心血管内科,广东广州510282

出　　处：《昆明医科大学学报》2020年第3期144-149,共6页Journal of Kunming Medical University

基　　金：国家自然科学基金地区基金资助项目(81860254);南方医科大学临床研究启动计划项目(LC2016ZD022)。

摘　　要：伊布利特是一种III类抗心律失常药物,是甲基磺酰胺的衍生物,结构与索他洛尔相似,目前临床上常运用于心房扑动(房扑)和心房颤动(房颤)的转复。然而,伊布利特在具有良好的抗心律失常疗效的同时,亦存在致室性心律失常的风险,故把握好伊布利特的适应征、禁忌征及不良反应发生时相应的处理措施十分重要。就伊布利特的作用机理及临床应用进展作一综述。Ibutilide,a derivative of methylsulfonamide,with the structure similar to sotalol,is a class III antiarrhythmic drug.It is used in atrial flutter and atrial fibrillation in clinical treatment.However,ibutilide is not only with a good effect of antiarrhythmic but also with a risk of ventricular arrhythmia.Therefore,it is very important to understand the indications,contraindications and the treatment of adverse reactions of ibutilide.This paper reviewed the mechanisms and clinical application progress of ibutilide.

关 键 词：伊布利特 心房颤动 心房扑动 

分 类 号：R962[医药卫生—药理学]