不同剂量盐酸氨溴索治疗婴幼儿百日咳前瞻性多中心临床研究  

Clinical effect of different doses of ambroxol hydrochloride in the treatment of pertussis in infants:a prospective multicenter clinical study

作　　者：周晓华[1] 杨奕校 林广裕[1] 林创兴[1] 蔡晓莹[1] 张丹桂 张旭东 连楚南[3] 郭佳群 谢鹤[5] 陈敬贤 ZHOU Xiaohua;YANG Yixiao;LIN Guangyu;LIN Chuangxing;CAI Xiaoying;ZHANG Dangui;ZHANG Xudong;LIAN Chunan;GUO Jiaqun;XIE He;CHEN Jingxian(Department of Pediatrics,the Second Affiliated Hospital of Shantou University Medical College,Shantou 515041,China;Department of Pediatrics,Shanwei Second People’s Hospital,Shanwei 516600,China;Department of Pediatrics,the First Affiliated Hospital of Shantou University Medical College,Shantou 515041,China;Department of Pediatrics,Chaozhou People’s Hospital,Chaozhou 521000,China;Department of Pediatrics,Chaozhou Central Hospital,Chaozhou 521000,China;Guangzhou Jinyu Medical Laboratory Center,Guangzhou 510330,China)

机构地区：[1]汕头大学医学院第二附属医院儿科,广东汕头515041 [2]汕尾市第二人民医院儿科,广东汕尾516600 [3]汕头大学医学院第一附属医院儿科,广东汕头515041 [4]潮州市人民医院儿科,广东潮州521000 [5]潮州市中心医院儿科,广东潮州521000 [6]广州金域医学检验中心,广东广州510330

出　　处：《汕头大学医学院学报》2020年第1期1-4,共4页Journal of Shantou University Medical College

基　　金：汕头市卫生科技计划医疗卫生类别项目[(2019)79号];广东省科技专项资金项目[汕府科(2019)113号135]。

摘　　要：目的:探讨不同剂量盐酸氨溴索(沐舒坦)治疗婴幼儿百日咳的临床疗效。方法:2018年9月至2019年3月汕头大学医学院第二附属医院等5家单位联合开展开放性、前瞻性、非随机对照临床研究,共收集百日咳核酸PCR阳性确诊的百日咳患儿64例,年龄<1岁,平均(5.28±4.96)月龄,其中男40例,女24例。根据患儿父母意愿分为对照组26例,观察组38例。所有患儿均给予阿奇霉素(10 mg/kg,1次/d,口服3 d)抗感染及对症治疗,对照组加用常规剂量盐酸氨溴索(7.5 mg,2次/d,静脉滴注2周),观察组加用大剂量盐酸氨溴索(10 mg/kg,2次/d,静脉滴注2周)。比较2组患儿痉挛性咳嗽治疗的有效率。结果:观察组治疗48 h、72 h及1周时的有效率均高于对照组(均P<0.05)。2组患儿痉挛性咳嗽持续时间、住院时间及出院前总有效率差异无统计学意义(P>0.05)。结论:大剂量盐酸氨溴索对婴幼儿百日咳的痉挛性咳嗽有明显的辅助治疗作用。Objective:To investigate the clinical effect of ambroxol hydrochloride(Mucosolvan)in different doses on pertussis in infants.Methods:From September 2018 to March 2019,5 units including the Second Affiliated Hospital of Shantou University Medical College jointly carried out an open,prospective and nonrandomized controlled clinical study.A total of 64 cases of pertussis confirmed by PCR positive pertussis were collected,with the age<1 year old and the average age of(5.28±4.96)months,including 40 males and 24 females.According to the parents’wishes,the children were divided into control group(26 cases)and observation group(38 cases).All the children were given azithromycin(10 mg/kg,once a day,oral 3 days)for antiinfection and symptomatic treatment.The control group was given ambroxol hydrochloride(7.5 mg,twice a day,intravenous drip for 2 weeks).The observation group was given ambroxol hydrochloride(10 mg/kg,twice a day,intravenous drip for 2 weeks).The effective rate of the treatment of spasmodic cough was compared between the two groups.Results:The effective rate of the observation group at 48 h,72 h and 1 week was higher than that of the control group(P<0.05).There was no significant difference between the two groups in the duration of spasmodic cough,hospital stay and the total effective rate before discharge(P>0.05).Conclusion:Large dose ambroxol hydrochloride has obvious auxiliary therapeutic effect on spasmodic cough of pertussis in infants.

关 键 词：百日咳 婴幼儿 氨溴索 沐舒坦 剂量 

分 类 号：R725.6[医药卫生—儿科]