126例急性腹泻患者粪便标本中细菌培养结果及主要致病菌对抗菌药物的耐药性分析  

Analysis on Bacterial Culture Results and Resistance of Main Pathogenic Bacteria in Stool Samples of 126 Patients with Acute Diarrhea

作　　者：刘振华 LIU Zhen-hua(Department of Infection and Digestion,Zhongmou County People's Hospital,Zhongmou He'nan 451450,China)

机构地区：[1]中牟县人民医院感染消化科,河南中牟451450

出　　处：《抗感染药学》2020年第2期183-186,共4页Anti-infection Pharmacy

摘　　要：目的:分析急性腹泻患者粪便标本中细菌培养结果及主要致病菌对抗菌药物的耐药性。方法:选取医院2018年12月—2019年11月间诊治的急性腹泻患者126例资料,统计其患者粪便标本中细菌培养及药敏试验结果,分析其病原菌的分布情况及耐药性。结果:126例急性腹泻患者粪便标本中,检出病原菌株99株,其检出率为78.57%,其中肠球菌属37株占29.37%、志贺菌属26株占20.63%;肠球菌属菌株对万古霉素、利奈唑胺的耐药性较低,而志贺菌属、克雷伯菌属、沙门菌属菌株对氨苄西林的耐药性较高。结论:急性腹泻患者粪便标本中致病菌主要为肠球菌属菌株,其次为志贺菌属;对于部分抗菌药物具有较高的耐药性,临床应在治疗前明确病原菌类型及其耐药性,以确保抗菌药物治疗的有效性。Objective:To analyze the results of bacterial culture in stool samples of patients with acute diarrhea and the resistance of main pathogenic bacteria to antibiotics.Methods:The data of 126 patients with acute diarrhea diagnosed and treated in the hospital from December 2018 to November 2019 were selected,and the results of bacterial culture and drug susceptibility test in the fecal samples of the patients were collected to analyze the distribution and drug resistance of pathogenic bacteria.Results:In the feces samples of 126 patients with acute diarrhea,99 strains of pathogenic bacteria were detected,and the detection rate was 78.57%,among which 37 strains of Enterococcus accounted for 29.37%and 26 strains of Shigella accounted for 20.63%.Enterococcus strains showed low resistance to vancomycin and linezolid,while Shigella,Klebsiella and Salmonella strains showed high resistance to ampicillin.Conclusion:Enterococcus and Shigella were the main pathogenic bacteria in fecal samples of patients with acute diarrhea,which have high resistance to some antibiotics.Therefore,the types of pathogens and their resistance should be identified before treatment to ensure the effectiveness of antimicrobial treatment.

关 键 词：急性腹泻 粪便标本 细菌培养 致病菌 抗菌药物 耐药性 

分 类 号：R969.3[医药卫生—药理学]