乌拉地尔与艾司洛尔对高血压全麻诱导压力反射敏感性的影响  

Effect of urapidil and esmolol on baroreflex sensitivity induced by general anesthesia

作　　者：杨宗雷 YANG Zonglei(Anesthesiology Department,Dingzhou City People’s Hospital,Hebei,Dingzhou 073000,China)

机构地区：[1]河北省定州市人民医院麻醉科,河北定州073000

出　　处：《中国医药科学》2020年第3期181-183,共3页China Medicine And Pharmacy

摘　　要：目的探讨乌拉地尔与艾司洛尔对高血压全麻诱导压力反射敏感性的影响。方法选取2017年2月~2018年12月本院收治的胆囊结石合并高血压患者80例,按照随机数字表法分为两组,各40例。所有患者均实施静脉快速诱导气管插管术,观察组给予艾司洛尔,对照组给予乌拉地尔,比较两组干预前后压力反射敏感性变化情况,及两组麻醉诱导时生命体征及血压将至预定值时间,统计两组干预期间发生的并发症。结果干预后两组压力反射敏感性显著高于干预前(P<0.05),且干预后观察组压力反射敏感性显著高于干预后对照组(P<0.05),观察组麻醉诱导时心率慢于对照组(P<0.05),平均动脉压低于对照组(P<0.05),血压降至预定值时间快于对照组(P<0.05),观察组麻醉诱导时发生低血压、高血压、心动过速及麻醉术后苏醒延迟的比例显著低于对照组(P<0.05)。结论针对原发性高血压实施全身麻醉患者,诱导前使用艾司洛尔能显著提高患者压力反射敏感性,促进生命体征平稳,减少对循环功能影响,促进患者术后恢复。Objective To discuss the effect of urapidil and esmolol on baroreflex sensitivity induced by general anesthesia.Methods 80 patients with gallstone and hypertension admitted to our hospital from February 2017 to December 2018 were selected and divided into observation group and control group by random number table method,with 40 cases in each group.All patients underwent intubation by intravenous fast induction.The observation group was given esmolol,while the control group was given urapidil.The changes of baroreflex sensitivity before and after intervention,vital signs during anesthesia induction and time of blood pressure reaching the predetermined value in two groups were compared.And the complications of the two groups were analyzed.Results The baroreflex sensitivity of the two groups after intervention was significantly higher than that before intervention(P<0.05),and after intervention,the baroreflex sensitivity of the observation group was significantly higher than that of the control group(P<0.05).The heart rate during anesthesia induction in the observation group was slower than that in the control group(P<0.05),the mean arterial pressure was lower than that of the control group(P<0.05),and the time of blood pressure reaching the predetermined value was faster than that of the control group(P<0.05).During anesthesia induction,the proportion of hypotension,hypertension,tachycardia and delayed recovery after anesthesia surgery in the observation group was significantly lower than those in the control group(P<0.05).Conclusion For patients with essential hypertension undergoing general anesthesia,esmolol before induction can significantly improve the baroreflex sensitivity,promote the stability of vital signs,reduce the impact of circulatory function,and promote the recovery of patients after operation.

关 键 词：艾司洛尔 乌拉地尔 高血压 全麻诱导 压力反射敏感性 

分 类 号：R614[医药卫生—麻醉学]