脐带间充质干细胞移植治疗强直性脊柱炎患者的效果分析  

Analysis on Effect of Umbilical Cord Mesenchymal Stem Cell Transplantation in the Treatment of Patients with Ankylosing Spondylitis

作　　者：苏鸿君[1] 邓雯[1] 冯佩[1] SU Hongjun;DENG Wen;FENG Pei(Sun Yat-sen Memorial Hospital of Sun Yat-sen University,Guangzhou 510120,China)

机构地区：[1]中山大学孙逸仙纪念医院,广东广州510120

出　　处：《临床医学工程》2020年第3期295-296,共2页Clinical Medicine & Engineering

摘　　要：目的探讨脐带间充质干细胞移植治疗强直性脊柱炎患者的临床效果。方法选取我院2016年2月至2019年1月收治的40例强直性脊柱炎患者,随机分为对照组和观察组各20例。对照组采用免疫及生物制剂治疗,观察组采用脐带间充质干细胞移植治疗,对比两组的临床治疗效果。结果观察组治疗总有效率高于对照组(P<0.05)。治疗后,观察组的血沉、细胞间黏附分子、血清TNF-α水平均低于对照组(P<0.05);治疗后1个月、3个月、6个月,观察组的疼痛程度评分、活动指数评分均低于对照组(P<0.05)。结论脐带间充质干细胞移植治疗强直性脊柱炎患者的效果显著,值得临床推广。Objective To analyze the clinical effect of umbilical cord mesenchymal stem cell transplantation in the treatment of patients with ankylosing spondylitis.Methods 40 patients with ankylosing spondylitis admitted to our hospital from February 2016 to January 2019 were selected and randomly divided into control group and observation group,with 20 cases in each group.The control group was treated with immune and biological agents,and the observation group was treated with umbilical cord mesenchymal stem cell transplantation.The clinical treatment effects were compared between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the levels of erythrocyte sedimentation,intercellular adhesion molecules and serum TNF-αin the observation group were lower than those in the control group(P<0.05).1 month,3 months and 6 months after treatment,the pain scores and activity index scores of the observation group were lower than those of the control group(P<0.05).Conclusions Umbilical cord mesenchymal stem cell transplantation in the treatment of patients with ankylosing spondylitis has significant effect,which is worthy of clinical promotion.

关 键 词：脐带间充质干细胞移植 强直性脊柱炎 免疫调节 组织损伤 

分 类 号：R593.23[医药卫生—内科学]