坦洛新缓释片联合尿石通丸治疗输尿管下段结石效果分析  

Analysis on curative effects of tamsulosin sustained-release tablets combined with niaoshitong pills in treatment of lower ureteral calculi

作　　者：钟占嫦 苏清华 沈海丹 蔡鲁锋 ZHONG Zhanchang;SU Qinghua;SHEN Haidan;CAI Lufeng(Department of Pharmacy,Huangjiang Hospital,Huangjiang Town,Guangdong,Dongguan 523750,China)

机构地区：[1]广东省东莞市黄江镇黄江医院药剂科,广东东莞523750

出　　处：《中国医药科学》2020年第2期243-246,共4页China Medicine And Pharmacy

摘　　要：目的探索输尿管下段结石患者行坦洛新缓释片联合尿石通丸治疗的效果。方法选取2017年3月~2018年3月本院收治的78例输尿管下段结石患者作为本研究对象,将其计算机式随机分组为对照组、观察组,两组输尿管下段结石患者各39例,两组患者均予以常规治疗,对照组在常规治疗的基础上行坦洛新缓释片治疗,研究组在对照组的基础上行尿石通丸治疗,随后对比两组患者的血尿素氮、血肌酐、血尿素水平、复发率、不良反应发生概率、止痛药物使用率、肾绞痛再发生率、视觉模拟疼痛评分、结石排出时间。结果观察组患者血尿素氮(5.63±0.63)mmol/L、血肌酐(95.51±7.81)μmol/L、血尿素水平(5.26±1.63)mmol/L、复发率(2.56%)、不良反应发生率(2.56%)、用药后3d的VAS评分(3.64±1.02)分、止痛药物再使用率(17.95%)、肾绞痛再发生率(20.51%)低于对照组,差异有统计学意义(P<0.05),结石排出时间(5.44±1.25)d短于对照组,总有效率(94.87%)高于对照组,差异有统计学意义(P<0.05)。结论对输尿管下段结石患者实施坦洛新缓释片联合尿石通丸治疗的效果显著,不仅能够缓解疼痛感,提高结石排除率,还能够改善肾功能,提高整体疗效,值得推广。Objective To explore the curative effects of tamsulosin sustained-release tablets combined with Niaoshitong pills in treatment of lower ureteral calculi.Methods 78 patients with lower ureteral calculi who were admitted and treated in our hospital from March 2017 to March 2018 were selected as the research objects.They were randomly divided into control group and observation group by computer,with 39 cases in each group.Patients in two groups were all given routine treatment.The control group was treated with tamsulosin sustained-release tablets on the basis of routine treatment while and the observation group was treated with Niaoshitong pills on the basis of the control group.Blood urea nitrogen,serum creatinine,blood urea level,recurrence rate,incidence of adverse reaction,using rate of analgesic drugs,recurrence rate of renal colic,visual analogue pain score and stone excretion time were compared between the two groups.Results The blood urea nitrogen(5.63±0.63)mmol/L,serum creatinine(95.51±7.81)μmol/L,urea level(5.26±1.63)mmol/L,recurrence rate(2.56%),incidence of adverse reactions(2.56%),VAS score of 3 days after treatment(3.64±1.02),reusing rate of analgesics(17.95%)and re-occurrence rate of renal colic(20.51%)in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).And stone excretion time(5.44±1.25)d was shorter than that of the control group and the total effective rate(94.87%)was higher than that of the control group,the difference was statistically significant(P<0.05).Conclusion Tamsulosin sustained-release tablets combined with Niaoshitong pills in treatment of patients with lower ureteral calculi has significant curative effects.It can not only relieve pain and improve stone removal rate,but also improve renal function and overall curative effects,which is worth promoting.

关 键 词：坦洛新缓释片 尿石通丸 输尿管下段结石 不良反应 

分 类 号：R693.4[医药卫生—泌尿科学]