新型六氢山酮素拼接异噁唑双螺环氧化吲哚类化合物的合成  

Synthesis of Novel Hexahydroxanthone-fused Isoxazole-based Bispirooxindoles

作　　者：汪军鑫 巩艺[1] 周英 刘雄利[1] 邓国栋[1] WANG Jun-xin;GONG Yi;ZHOU Ying;LIU Xiong-li;DENG Guo-dong(Guizhou Medicine Edicine Edible Plant Resources Research and Developmant Center,Guizhou University,Guiyang 550025,China;College of Pharmaceutical Sciences,Guizhou University of Chinese Medicine,Guiyang 550025,China)

机构地区：[1]贵州大学贵州省药食同源植物资源开发工程技术研究中心,贵州贵阳550025 [2]贵州中医药大学药学院,贵州贵阳550025

出　　处：《合成化学》2020年第2期118-122,共5页Chinese Journal of Synthetic Chemistry

基　　金：贵州省科技项目(黔科合J字[2009]2321号)。

摘　　要：以色酮-氧化吲哚合成子1与氧化吲哚3-烯烃硝基异噁唑2,在催化剂DABCO催化下,在氯仿中发生双Michael加成环化反应,合成了7个未见文献报道的六氢山酮素拼接异噁唑双螺环氧化吲哚类化合物3a^3g,产率78%~92%,dr值10/1~15/1,其结构经^1H NMR,^13C NMR和HR-MS(ESI-TOF)表征。Seven new hexahydroxanthone-fused isoxazole-based bispirooxindoles(3 a^3 g)were synthesized via an DABCO-catalyzed dual Michael cycloaddition of cHR-omone-oxindole synthons 1 with 5-isatylidenyl-isoxazoles 2 at room temperature in CHCl3 for 3 d. The yields and dr of 3 a^3 g were 78%~92% and 10/1~15/1, respectively. The structures of products were characterized by ^1H NMR, ^13C NMR and HR-MS(ESI-TOF).

关 键 词：氧化吲哚-色酮合成子 异噁唑 双Michael加成环化反应 六氢山酮素 合成 

分 类 号：O626.13[理学—有机化学] O623.7[理学—化学]