新型色满酮并环己烷螺环氧化吲哚类化合物的合成  

Synthesis of Novel Spiro [hexahydrocyclohexa [b] chromanone-oxindole]s

作　　者：高月 姚一鸣 常顺琴 刘雄利[1] 田民义 GAO Yue;YAO Yi-ming;CHANG Shun-qin;LIU Xiong-li;TIAN Min-yi(Guizhou Medicine Edicine Edible Plant Resources Research and Developmant Center,Guizhou University,Guiyang 550025,China)

机构地区：[1]贵州大学贵州省药食同源植物资源开发工程技术研究中心,贵州贵阳550025

出　　处：《合成化学》2020年第2期148-152,共5页Chinese Journal of Synthetic Chemistry

基　　金：贵州大学培育项目(黔科合平台人才[2018]5781-49号)。

摘　　要：以色酮-氧化吲哚合成子与硝基苯乙烯,在催化剂DBU作用下,在二氯甲烷中发生Michael/Michael加成环化反应,合成了9个未见文献报道的新型色满酮并环己烷螺环氧化吲哚类化合物3a^3i,产率72%~87%,dr值4/1~2/1,其结构经^1H NMR,^13C NMR和HR-MS(ESI-TOF)表征确定。Nine novel spiro[hexahydrocyclohexa[b]chromanone-oxindole]s(3 a^3 i)were synthesized via an DBU-catalyzed Michael/Michael cycloaddition of chromone-oxindole synthons 1 with nitroolefins 2 under room temperature conditions in CH2Cl2 for 1 d. The yields and dr of 3 a^3 i were 72%~87% and 4/1~2/1, respectively. The structures of products were characterized by ^1H NMR, ^13C NMR and HR-MS(ESI-TOF).

关 键 词：氧化吲哚-色酮合成子 硝基苯乙烯 Michael/Michael加成环化反应 螺环 合成 

分 类 号：O626.13[理学—有机化学] O623.7[理学—化学]