完全性生长激素缺乏患儿中央沟形态变化的磁共振诊断价值  

Morphological changes of the central sulcus in children with complete growth hormone deficiency:a 3.0 T MRI study

作　　者：张琪 王宇 林祥涛 许飞飞 侯中煜[1] 李卓然 于乔文 王锡明[1] 刘树伟 李若川 张忠和[1] Zhang Qi;Wang Yu;Lin Xiangtao;Xu Feifei;Hou Zhongyu;Li Zhuoran;Yu Qiaowen;Wang Ximing;Liu Shuwei;Li Ruochuan;Zhang Zhonghe(Department of Medical Imaging,Shandong Provincial Hospital Affiliated to Shandong University,Jinan 250021,China;Research Center for Sectional and Imaging Anatomy,Shandong University Cheeloo College of Medicine,Jinan 250012,China;School of Basic Medical Science,Shandong First Medical University,Taian 271000,China)

机构地区：[1]山东大学附属省立医院医学影像科,济南250021 [2]山东大学齐鲁医学院断层影像解剖学研究中心,济南250012 [3]山东第一医科大学基础医学院,泰安271000

出　　处：《中华医学杂志》2020年第3期182-186,共5页National Medical Journal of China

摘　　要：目的分析完全性生长激素缺乏(CGHD)患儿大脑皮质中央沟的形态变化。方法回顾性分析2015年1月至2019年1月山东省立医院确诊的30例CGHD患儿(男18例、女12例,年龄5~14岁)与30例特发性矮小患儿(男22例、女8例,年龄5~14岁)。利用Brain VISA软件获得中央沟的平均宽度、最大深度、平均深度、顶长、底长和不同位点的脑沟深度(DPP),分析组间差异。应用秩和检验、χ^2检验分析组间年龄、性别差异。形态学参数的组间比较应用协方差分析。结果CGHD组双侧中央沟平均宽度[左:(2.26±0.41)mm,右:(2.19±0.34)mm]显著高于特发性矮小组[左:(2.10±0.27)mm,右:(2.02±0.18)mm](P<0.05);左侧中央沟最大深度[(19.67±1.29)mm]与右侧中央沟平均深度[(14.18±1.41)mm]显著低于特发性矮小组[左侧最大深度:(20.69±1.43)mm;右侧平均深度:(14.92±1.21)mm](P<0.05)。左侧中央沟中部(位点46~54)及右侧中央沟下部(位点91~98)CGHD组的DPP显著低于特发性矮小组。结论CGHD患儿存在显著的中央沟形态变化,这可能是其运动、认知与语言功能发育相对落后的结构基础。Objective To analyze morphological changes in central sulcus of the cerebral cortex in children with complete growth hormone deficiency(CGHD).Methods Patients attending the Shandong Provincial Hospital who were diagnosed with CGHD or idiopathic short stature were recruited from January 2015 to January 2019.Thirty children with CGHD(18 males and 12 females,5 to 14 years old)and 30 children with idiopathic short stature(22 males and 8 females,5 to 14 years old)were included.Measurements of the central sulcus,including the average width,maximum depth,average depth,top length,bottom length and depth position-based profiles(DPP),were obtained using Brain VISA software.The significant differences between groups were statistically analyzed.Results The average width of bilateral central sulci in children with CGHD(left:(2.26±0.41)mm;right:(2.19±0.34)mm)were significantly higher than those in children with idiopathic short stature(left:(2.10±0.27)mm;right:(2.02±0.18)mm)(P<0.05);The maximum depth of the left central sulcus((19.67±1.29)mm)and the average depth of the right central sulcus((14.18±1.41)mm)were significantly lower than those in children with idiopathic short stature(left maximum depth:(20.69±1.43)mm;right average depth:(14.92±1.21)mm)(P<0.05).Children with CGHD had significantly lower DPP at the middle part of the left central sulcus(sites:46-54)and the inferior part of the right central sulcus(sites:91-98).Conclusion There are significant morphological changes of the central sulcus in children with CGHD,which may represent the structural basis of their relatively slower development in motor,cognitive and linguistic functional performance.

关 键 词：人生长激素 侏儒症 垂体性 磁共振成像 

分 类 号：R72[医药卫生—儿科] R44[医药卫生—临床医学]