一锅法合成新型羟基环戊烯酮化合物  

One-pot Synthesis of Novel Hydroxycyclopentenone Compounds

作　　者：陈卫达 马永敏[1,2] CHEN Wei-da;MA Yong-min(Collegel of Pharmaceutical Science,Zhejiang Chinese Medical University,Hangzhou 311400,China;School of Advanced Study,Taizhou University,Taizhou 318000,China)

机构地区：[1]浙江中医药大学药学院,浙江杭州311400 [2]台州学院高等研究院,浙江台州318000

出　　处：《合成化学》2020年第3期202-208,共7页Chinese Journal of Synthetic Chemistry

基　　金：浙江省自然科学基金资助项目(YH17H300005)。

摘　　要：以二芳基乙酮(4a^4f)和取代丙酮(5a^5c)为原料,KHCO3为碱,100℃空气条件下,在DMSO中经二芳基乙酮氧化、羟醛缩合一锅法合成了12个羟基环戊烯酮化合物(6a^6l),其中6d, 6h和6i为新化合物,其结构经1H NMR,13C NMR和HR-MS(ESI)表征。Hydroxycyclopentenone compounds(6 a^6 l) were synthesized via one-pot method at 100 ℃, using diaryl acetophenone compounds(4 a^4 f) and substituted acetone compounds(5 a^5 c) as starting materials, KHCO3 as base, DMSO as solvent, consisting of diphenylacetone oxidation and aldol condensation. Among them, 6 d, 6 h and 6 i were novel compounds. The structures were characterized by 1H NMR, 13C NMR and HR-MS(ESI).

关 键 词：一锅法 羟基环戊烯酮 二芳基乙酮 取代丙酮 羟醛缩合 合成 

分 类 号：O626[理学—有机化学]