慢性阻塞性肺疾病与衰老调控机制的研究进展  

Research progress on chronic obstructive pulmonary disease and mechanisms underlying its regulation of aging

作　　者：曹开秀 李争 王先敏 Cao Kaixiu;Li Zheng;Wang Xianmin(The Fourth Clinical Medical College,Xinjiang Medical University,Urumqi 830000,China;Department of Respiratory Medicine,Fourth Clinical Medical College of Xinjiang Medical University,Urumqi 830000,China;Department of Scientific Research,Fourth Clinical Medical College of Xinjiang Medical University,Urumqi 830000,China)

机构地区：[1]新疆医科大学第四临床医学院,乌鲁木齐830000 [2]新疆医科大学第四临床医学院呼吸科,乌鲁木齐830000 [3]新疆医科大学第四临床医学院科研科,乌鲁木齐830000

出　　处：《中华老年医学杂志》2020年第2期241-244,共4页Chinese Journal of Geriatrics

基　　金：国家自然科学基金项目(81660739);国家中医药管理局国家中医临床研究基地业务建设科研专项课题(JDZX2015239)。

摘　　要：慢性阻塞性肺疾病(COPD)是一种呼吸系统常见病,具有较高的致残率和致死率,已成为全世界关注的主要公共卫生问题之一。其特征在于异常的组织修复导致的(小)气道疾病和肺气肿,但其发病机制目前仍不明确。新的观点指出,COPD是一种加速的肺老化疾病,衰老所涉及的相关调控机制如端粒/端粒酶、表观遗传的改变、线粒体功能障碍等均与COPD密切相关。本文就COPD与衰老相关调控机制的研究进展进行综述。Chronic obstructive pulmonary disease(COPD)is a common respiratory disease with a high disability and mortality rate,and it has become one of the major public health issues of concern worldwide.It includes small airway disease and emphysema caused by abnormal tissue repair,but its pathogenesis is still unclear.COPD is currently viewed as a disease of accelerated lung aging and is closely associated with aging mechanisms such as telomere/telomerase,epigenetic changes and mitochondrial dysfunction.This article reviews research progress on the mechanisms linking COPD and aging-related regulation.

关 键 词：肺疾病 慢性阻塞性 衰老 调控序列 核酸 

分 类 号：R563[医药卫生—呼吸系统]