舌下免疫法治疗变应性鼻炎对患者鼻通气功能改善的客观评估  

Objective Evaluation of the Improvement of Nasal Ventilation Function in Patients with Allergic Rhinitis Treated by Sublingual Immunotherapy

作　　者：施思斯[1] 张超[1] 于青青[1] 白晶 王凯[1] SHI Sisi;ZHANG Chao;YU Qingqing;BAI Jing;WANG Kai(Foshan First People’s Hospital,Foshan 528000,China)

机构地区：[1]广东省佛山市第一人民医院,广东佛山528000

出　　处：《中国医学创新》2020年第8期153-156,共4页Medical Innovation of China

基　　金：广东省自然科学基金项目(2015A030313771);佛山市科技局科研基金项目(2016AB002611)。

摘　　要：目的:探讨舌下免疫法治疗变应性鼻炎对患者鼻通气功能改善的客观评估方法。方法:选择2016年3月-2018年3月本院收治的行舌下免疫法治疗的变应性鼻炎患者73例,患者均应用舌下免疫法治疗变应性鼻炎,分别于治疗前和治疗3、6、12个月后进行鼻声反射检测和鼻阻力检测,比较各时间点鼻腔最小横截面积(NMCA)、最小横截面距前鼻孔距离(DCAN)、0~5 cm距离的单侧和双侧鼻腔容积(NCV)、单侧和双侧鼻阻力值(NR)等观察指标。结果:治疗3、6、12个月后,患者的NMCA、单侧NCV、双侧NCV均高于治疗前,DCAN、单侧NR、双侧NR均低于治疗前(P<0.05);治疗6、12个月后,患者的NMCA、单侧NCV、双侧NCV均高于治疗3个月,DCAN、单侧NR、双侧NR均低于治疗3个月(P<0.05);治疗6、12个月后,患者的NMCA、DCAN、单侧NCV、双侧NCV、单侧NR、双侧NR比较,差异均无统计学意义(P>0.05)。结论:变应性鼻炎患者应用舌下免疫法治疗后,鼻声反射和鼻阻力客观检查数据均得到明显改善,鼻声反射和鼻阻力客观检查数据可作为舌下免疫法治疗变应性鼻炎对患者鼻通气功能改善的客观评估指标,具有一定的临床参考价值。Objective:To investigation the objective evaluation method of sublingual immunotherapy for allergic rhinitis on the improvement of nasal ventilation function.Method:A total of 73 patients with allergic rhinitis treated by sublingual immunotherapy from March 2016 to March 2018 in our hospital were selected,all patients were treated with sublingual immunotherapy for allergic rhinitis.Nasal acoustic reflex and nasal resistance were detected before treatment and 3,6,12 months after treatment.The minimum nasal cross-sectional area (NMCA),minimum cross-sectional distance from the anterior nostril (DCAN),unilateral and bilateral nasal volume (NCV),unilateral and bilateral nasal resistance value (NR) at 0-5 cm were compared at each time point.Result:After 3,6,12 months of treatment,patients’ NMCA,unilateral NCV and bilateral NCV were all higher than those before treatment,DCAN,unilateral NR and bilateral NR were all lower than those before treatment (P<0.05).After 6,12 months of treatment,the NMCA,unilateral NCV and bilateral NCV of the patients were all higher than those after 3 months of treatment,DCAN,unilateral NR and bilateral NR were all lower than those after (P<0.05).After 6,12 months of treatment,comparison of patients’ NMCA,DCAN,unilateral NCV,bilateral NCV,unilateral NR and bilateral NR,the differences were not statistically significant (P>0.05).Conclusion:After the treatment of allergic rhinitis with supraglossal immunotherapy,the objective examination data of nasal acoustic reflex and nasal resistance were significantly improved.The objective examination data of nasal acoustic reflex and nasal resistance could be used as objective evaluation indexes for the improvement of nasal ventilation function of patients with allergic rhinitis treated with supraglossal immunotherapy,which has certain clinical reference value.

关 键 词：变应性鼻炎 舌下免疫法 鼻通气功能 客观评估 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]