冠心病患者的他汀撤药综合征研究进展  

Statin withdrawal syndrome in patients with coronary heart disease

作　　者：伍满燕 梁文卿 陈红[1] Wu Manyan;Liang Wenqing;Chen Hong(Department of Cardiology,Peking University People′s Hospital,Beijing Key Laboratory of Early Prediction and Intervention of Acute Myocardial Infarction,Center for Cardiovascular Translational Research,Peking University People′s Hospital,Beijing 100044,China)

机构地区：[1]北京大学人民医院心内科,急性心肌梗死早期预警和干预北京市重点实验室,北京大学人民医院心血管转化医学研究中心,100044

出　　处：《中华全科医师杂志》2020年第2期141-144,共4页Chinese Journal of General Practitioners

基　　金：国家自然科学基金(81770356)。

摘　　要：他汀类药物可以有效防治心脑血管事件,是抗动脉粥样硬化的一线药物。然而,许多研究发现,患者对他汀类药物的依从性差,停药率高。停用他汀类药物会导致心脑血管事件的发生和死亡风险反弹性升高,引起他汀撤药综合征。现对相关研究及可能的机制进行综述,以期引起临床医生的重视,避免患者他汀类药物的撤药综合征。Statins,as the first-line anti-atherosclerosis drugs,are of significant benefit in reducing the risk for cardiovascular and cerebrovascular events.However,many studies have shown that the patient adherence to statin is poor in clinical practice,and many cardiovascular patients abruptly discontinue therapy.Acute withdrawal of statin therapy may have a rebound effect on patient outcomes,and clinicians should pay attention to statin withdrawal syndrome to avoid its occurence.

关 键 词：冠心病 他汀撤药综合征 机制 

分 类 号：R541[医药卫生—心血管疾病]