2016~2018年我院抗菌药物的使用及细菌耐药性分析  

Analysis of antimicrobial drug use and bacterial resistance in our hospital from 2016 to 2018

作　　者：王美玲 WANG Meiling(Department of Pharmacy,Nantong Hospital of Traditional Chinese Medicine,Jiangsu Province,Nantong 226001,China)

机构地区：[1]江苏省南通市中医院药剂科,南通226001

出　　处：《西北药学杂志》2020年第2期304-308,共5页Northwest Pharmaceutical Journal

摘　　要：目的分析医院住院患者的细菌耐药性与抗菌药物使用频度(DDDs)的相关性,为临床合理用药提供参考。方法回顾调查分析我院住院患者细菌耐药性与DDDs,使用Pearson相关法对二者进行相关性分析。结果2016~2018年革兰阴性(G-)杆菌检出率前4位分别为大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌和鲍曼不动杆菌。二代头孢、三代头孢、左氧氟沙星、阿莫西林克拉维酸钾、莫西沙星和哌拉西林钠/他唑巴坦钠的DDDs排序居前。大肠埃希菌的耐药率与头孢西丁、头孢呋辛的DDDs呈正相关(r值分别为0.917和0.866,P值均小于0.05);铜绿假单胞菌的耐药率与头孢呋辛的DDDs呈正相关(r=0.895,P<0.05);肺炎克雷伯菌的耐药率与左氧氟沙星的DDDs呈正相关(r=0.994,P<0.05);鲍曼不动杆菌的耐药率与哌拉西林钠/他唑巴坦钠、头孢呋辛、头孢他啶和美罗培南的DDDs呈正相关(r值分别为0.887,0.895,0.869和0.870,P值均小于0.05)。结论我院DDDs与G-杆菌耐药性有一定的相关性,必须规范临床科学合理使用抗菌药物,才能有效延缓细菌耐药性的产生和发展。Objective To analyze the correlation between bacterial drug resistance and the frequency of antibacterial drug use(DDDs)in patients in our hospital,and to provide reference for clinical rational drug use.Methods Retrospective investigation and analysis of bacterial drug resistance and DDDs of inpatients in our hospital were performed by using Pearson correlation method.Results E Scherichia coli,Klebsiella pneumoniae,Pseudomonas aeruginosa and Acinetobacter baumannii were the top 4 positive rates of G-bacilli in our hospital from 2016 to 2018.The second and third generation cephalosporins,levofloxacin,amoxicillin clavulanate potassium,meroxacin,piperacillin tazobactam,meloxicillin,azithromycin,cefoperazone sulbactam,meropenem and gentamicin ranked first in DDDs sequence.The resistance rate of Escherichia coli to cefoxitin and cefuroxime was positively correlated with DDDs(r=0.917 and 0.866,P<0.05).The drug resistance rate of Pseudomonas aeruginosa was positively correlated with cefuroxime DDDs(r=0.895,P<0.05).The drug resistance rate of Acinetobacter baumannii was positively correlated with DDDs of piperacillin tazobactam,cefuroxime,ceftazidime and meropenem(r=0.887,0.895,0.869 and 0.870,P<0.05).Conclusion The DDDs in our hospital is related to the drug resistance of G-bacilli.In order to effectively control the occurrence and development of bacterial drug resistance,clinical rational use of antibacterial drugs must be standardized.

关 键 词：抗菌药物 抗菌药物使用频度 细菌耐药性 相关性 

分 类 号：R969.3[医药卫生—药理学]