青蒿素类药物缓解自身免疫病及其机制的研究现状  

Research Progress of Effect of Artemisinin Family Drugs on Alleviating Autoimmune Diseases and Their Mechanisms

作　　者：谢宜 倪宇雯 朱泽宇 樊卫平[1] XIE Yi;NI Yuwen;ZHU Zeyu;FAN Weiping(Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学,山西太原030001

出　　处：《中国医学创新》2020年第7期163-167,共5页Medical Innovation of China

基　　金：山西省专利推广实施资助专项项目(20171009)。

摘　　要：近年来研究发现青蒿素类抗疟药物具有免疫抑制及免疫调节活性,可以抑制CD4^+炎性T细胞如Th1、Th17,提高免疫抑制细胞Treg比例,治疗自身免疫病,但其具体作用机制尚不十分清楚。自身免疫病大多为慢性或进行性疾病,需要长期用药。激素类药物及免疫抑制剂作为治疗自身免疫病的传统药物,长期使用存在免疫抑制、继发感染、代谢紊乱等严重的副作用,因此临床上迫切需要高效低毒的替代药物。本文就青蒿素类药物缓解类风湿关节炎、系统性红斑狼疮、多发性硬化、自身免疫肝炎、IgA肾病和炎症性肠病等自身免疫病的作用及相关机制进行综述。Researches have found that artemisinin-based antimalarial drugs have immunosuppressive and immunoregulatory activities,which can inhibit CD4^+inflammatory T cells such as Th1 and Th17,improve the proportion of immunosuppressive cells Treg,and treat autoimmune diseases,but the mechanism is still unclear.Most autoimmune diseases are chronic or progressive diseases and require long-term medication.Long-term using of hormones or immunosuppressor,the traditional medication,usually arouses serious side effects such as immunosuppression,secondary infection and metabolic disorders.Therefore,it is urgent to replace traditional hormones with new high-efficiency and low-toxicity drugs.In this paper,artemisinin drugs to alleviate rheumatoid arthritis,systemic lupus erythematosus,multiple sclerosis,autoimmune hepatitis,IgA nephropathy,inflammatory bowel disease and other autoimmune diseases and related mechanisms were reviewed.

关 键 词：青蒿素 自身免疫病 免疫调节 免疫抑制 

分 类 号：R285[医药卫生—中药学]