Brachyury基因在胚胎发育过程中的重要作用相关研究进展  

Advances in Research on the Important Role of Brachyury Gene during Embryonic Development

作　　者：苏红 智达夫 杨光 王彤 田志鹏 曹贵方[1] SU Hong;ZHI Da-fu;YANG Guang;WANG Tong;TIAN Zhi-peng;CAO Gui-fang(College of Veterinary Medicine,Inner Mongolia Agricultural University,Hohhot 010018,China;Inner Mongolia Key Laboratory of Basic Veterinary Science,Hohhot 010018,China;College of Life Science,Inner Mongolia Agricultural University,Hohhot 010018,China)

机构地区：[1]内蒙古农业大学兽医学院,内蒙古呼和浩特010018 [2]内蒙古自治区基础兽医学重点实验室,内蒙古呼和浩特010018 [3]内蒙古农业大学生命科学学院,内蒙古呼和浩特010018

出　　处：《畜牧与饲料科学》2020年第2期13-17,共5页Animal Husbandry and Feed Science

基　　金：国家自然科学基金项目(3186130045)。

摘　　要：Brachyury(T)基因是T-box家族中第一个被鉴定出来的基因,该家族也因此得名。科学家们一直在探索Brachyury基因和T-box家族各成员的分子结构和生理功能,研究发现,Brachyury基因在多种动物中同源性都比较高,这说明T基因在进化过程中高度保守;Brachyury基因在哺乳动物胚胎发育过程中对脊索、尾芽和尿囊的形成起到不可或缺的作用,而导致胚胎发育出现障碍的原因极有可能是Brachyury基因的改变引起了与Wnt和FGF信号通路相关因子表达的上调或下调;后来的研究还发现,动物短尾表型的形成似乎也与Brachyury基因在胚胎发育期间的表达有密切关系。基于国内外对Brachyury基因的研究现状,对Brachyury基因同源性和其在胚胎发育期间所起到的调控作用进行整理归纳,以期为相关研究提供参考。Brachyury(T)gene is the first identified gene in the T-box family,hence the name of the gene family was obtained.Scientists have been exploring the molecular structure and physiological functions of Brachyury genes and members of the T-box family.Studies have found that Brachyury gene has high homology in various animal species,which indicates that the T gene is highly conserved during the evolution process.Brachyury gene plays an indispensable role in the formation of notochord,tail buds and allantois during mammalian embryonic development,and the cause of the impediment in embryonic development is most likely the up-regulation or down-regulation of factors related to the Wnt and FGF signaling pathways induced by the changes in the Brachyury gene.Later researches have also found that the formation of the short tail phenotype in animals also seems to be closely associated with the expression of the Brachyury gene during embryonic development.Based on the research status of Brachyury gene at home and abroad,we summarized the homology of Brachyury gene and its regulatory role during embryonic development,in hoping to provide a reference for related researches.

关 键 词：Brachyury基因 胚胎发育 短尾表型 研究进展 

分 类 号：Q789[生物学—分子生物学]