A 16-channel high-voltage reconfigurable and flexible-controlled implantable wireless closed-loop system for SCI repair  

作　　者：Yan Hanbing Zhang Xu Liu Ming Yuan Fang Wang Sikai Chen Hongda 闫寒冰;Zhang Xu;Liu Ming;Yuan Fang;Wang Sikai;Chen Hongda(State Key Laboratory on Integrated Optoelectronics,Institute of Semiconductors,Chinese Academy of Sciences,Beijing 100083,P.R.China;University of Chinese Academy of Sciences,Beijing 100049,P.R.China)

机构地区：[1]State Key Laboratory on Integrated Optoelectronics,Institute of Semiconductors,Chinese Academy of Sciences,Beijing 100083,P.R.China [2]University of Chinese Academy of Sciences,Beijing 100049,P.R.China

出　　处：《High Technology Letters》2020年第1期79-84,共6页高技术通讯（英文版）

基　　金：Supported by the National Natural Science Foundation of China(No.61474107);the National Key Technologies R&D Program(No.2016YFC0105604)。

摘　　要：An adaptive closed-loop system for spinal cord injury(SCI) repair is designed. It integrates stimulation and recording on 16 pairs of electrodes. Two switches(SAS3 T16/SAS1 T16 X2) fabricated in high-voltage 0.8 μm process with online re-configurable function are proposed. These two switches are combined with commercial off-the-shelf(COTS) electronics to implement the closed-loop implantable system in compact module. The system includes amplifier for recording neural signals, high-voltage stimulator, power transmission device, central processing module and flexible implantable electrodes. Two customized switches route any electrode to amplifier or stimulator, and nerve stimulation and signal recording are performed through lead wire-driven channels. The entire system is able to operate at up to 28 V, and is a biocompatible package with a volume of 42 mm×35 mm×8 mm. This system solves several problems encountered in implantable devices: low flexibility, negative influence of stimulus artifacts on neural detection and low integration of electrodes.

关 键 词：spinal CORD injury(SCI)repair IMPLANTABLE medical device MULTI-ELECTRODE array RECONFIGURABLE system functional electrical stimulation 

分 类 号：TH789[机械工程—仪器科学与技术] TN409[机械工程—精密仪器及机械]