超声提取-单颗粒电感耦合等离子质谱法测定牙膏中纳米银颗粒  

Determination of Silver Nanoparticles in Toothpaste by Single Particle-Inductively Coupled Plasma-Mass Spectrometry with Ultrasonic Extraction

作　　者：史瑞新[1] 赵艳萍 管鹏 梁维新 荀合 SHI Rui-Xin;ZHAO Yan-Ping;GUAN Peng;LIANG Wei-Xin;XUN He((Hospital of Stomatology,Jilin University,Changchun 130022,China;Guangdong Provincial Key Laboratory of Emergency Test for Dangerous Chemicals,Guangdong Institute of Analysis,Guangzhou 510070,China)

机构地区：[1]吉林大学口腔医院,长春130022 [2]广东省化学危害应急检测技术重点实验室广东省测试分析研究所,广州510070

出　　处：《分析化学》2020年第4期523-529,共7页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金项目(No.21777150);广州市民生科技专项(No.201863030042)资助。

摘　　要：建立了超声提取-单颗粒电感耦合等离子体质谱法(Single particle-inductively coupled plasma-mass spectrometry,SP-ICP-MS)同时测定牙膏中纳米银颗粒(AgNPs)的粒径分布、数量浓度和质量浓度的方法。以0.1%Tx-100超声提取牙膏中的AgNPs,在SP-ICP-MS模式下测定牙膏中AgNPs的粒径分布、数量浓度和质量浓度,考察了方法的最佳提取时间、准确性和检出限。实验结果表明:最佳提取时间为10 min,采用SP-ICP-MS法测定不同粒径的AgNPs标准品,测定结果与标准值一致;方法的粒径检出限、数量浓度检出限和质量浓度检出限分别为23 nm、3.9×10^8 particles/kg和26 ng/kg;在牙膏样品的加标回收实验中,纳米颗粒回收率在86.6%~93.8%之间。本方法简单、快速,为牙膏中AgNPs的测定提供了准确的方法。A ultrasonic extraction combining single particle-inductively coupled plasma-mass spectrometry(SP-ICP-MS)method was developed to detect the size distribution,number concentrations and mass concentrations of silver nanoparticles(AgNPs)in toothpaste.AgNPs in toothpaste were extracted by sonication with 0.1% Tx-100 solvent,and SP-ICP-MS method was used for the determination of size distribution,number concentration and mass concentration of the AgNPs.The optimum extraction time,accuracy,detection limit of particle size,number concentration and mass concentration of the method were investigated.The result showed that in the optimum extraction time of 10 min,the particle sizes of AgNPs in diluent of toothpaste determined by SP-ICP-MS were consistent with the standard values provided by the manufacturer.The detection limits of particle size,number concentration and mass concentration were 23 nm,3.9×10^8 particles/kg and 26 ng/kg,respectively.The spiking recoveries of AgNPs in toothpaste were 86.6%-93.8%.The proposed method showed high sensitivity and accuracy in determination of size distribution and number concentrations of AgNPs in toothpaste.

关 键 词：纳米银颗粒 单颗粒电感耦合等离子体质谱法 牙膏 

分 类 号：O657.63[理学—分析化学] TQ658.41[理学—化学]