辅酶Q10对类风湿关节炎患者促炎症细胞因子和氧化应激水平的影响  

Effects of coenzyme Q10 on levels of proinflammatory cytokines and oxidative stress in patients with rheumatoid arthritis

作　　者：朱科达 王凛介 刘风云 顾惠英 ZHU Ke-da;WANG Lin-jie;LIU Feng-yun;GU Hui-ying(Department of Rheumatology and Immunology,Zhangjiagang Hospital of Traditional Chinese Medicine,Zhangjiagang 215600,China)

机构地区：[1]江苏省张家港市中医医院风湿免疫科,张家港市215600

出　　处：《广西医学》2020年第4期417-420,460,共5页Guangxi Medical Journal

基　　金：江苏省张家港市科技支撑计划(社会发展)(ZKS1739)。

摘　　要：目的探讨辅酶Q10对类风湿关节炎(RA)患者促炎症细胞因子和氧化应激水平的影响。方法将90例RA患者随机分为观察组和对照组,每组45例。对照组给予安慰剂、甲氨蝶呤、小剂量泼尼松治疗,观察组患者予以30 mg/d辅酶Q10、甲氨蝶呤、小剂量泼尼松治疗。比较两组患者促炎症细胞因子、丙二醛、免疫球蛋白水平,以及症状和体征改善情况等临床疗效。结果治疗后,观察组白细胞介素17、肿瘤坏死因子α、丙二醛、血沉、IgM、C反应蛋白水平均低于治疗前及对照组;两组患者症状和体征均较治疗前改善,但观察组关节疼痛评分及晨僵时间均少于对照组,治疗总有效率高于对照组(均P<0.05)。结论在常规治疗基础上,采用辅酶Q10治疗可以降低RA患者促炎症因子及氧化应激水平。Objective To investigate the effects of coenzyme Q10 on the levels of proinflammatory cytokines and oxidative stress in patients with rheumatoid arthritis(RA).Methods Ninety patients with RA were randomly divided into observation group and control group,with 45 cases in each group.The control group received placebo,methotrexate and low dose of prednisone,while the observation group received 30 mg/d coenzyme Q10,methotrexate and low dose of prednisone.The levels of proinflammatory cytokines,malondialdehyde and immune globulin,as well as efficacy such as symptoms and signs improvements were compared between the two groups.Results After treatment,the observation group had lower levels of interleukin 17,tumor necrosis factorα,malondialdehyde,erythrocyte sedimentation rate,IgM and C-reactive protein as compared with the control group and pretreatment;symptoms and signs of patients were improved in both groups in contrast with those before treatment,however,the observation group exhibited lower scores for joint pain,less duration of morning stiffness,and higher total effective rate for treatment in comparison with the control group(all P<0.05).Conclusion On the basis of conventional treatment,coenzyme Q10 use can reduce the levels of proinflammatory cytokines and oxidative stress in patients with RA.

关 键 词：辅酶Q10 类风湿关节炎 炎症因子 促炎症细胞因子 氧化应激 疗效 

分 类 号：R593.22[医药卫生—内科学]