HBV介导的肝星状细胞和天然免疫细胞的相互作用  

Hepatitis B virus-mediated interaction between hepatic stellate cells and innate immune cells

作　　者：杨苗苗 邬志惠 涂正坤[1] YANG Miaomiao;WU Zhihui;TU Zhengkun(Research Institute of Translational Medicine, The First Hospital of Jilin University, Changchun 130021, China)

机构地区：[1]吉林大学第一医院转化医学研究院,长春130021

出　　处：《临床肝胆病杂志》2020年第4期891-894,共4页Journal of Clinical Hepatology

基　　金：国家自然科学基金项目(81373143,81571535)。

摘　　要：肝脏非实质细胞在HBV相关的肝脏疾病中发挥着至关重要的作用,而肝星状细胞(HSC)的激活以及与肝内细胞之间的相互作用是导致肝纤维化的主要原因。主要介绍了HBV诱导的肝脏炎症以及天然免疫细胞与HSC的相互作用,简述了HBV作用下单核/巨噬细胞和自然杀伤细胞(NK细胞)对HSC的激活和杀伤作用以及HSC的肝脏免疫调节作用。Liver nonparenchymal cells play an important role in hepatitis B virus(HBV)-related liver diseases,and the activation of hepatic stellate cells(HSCs)and their interactions with intrahepatic cells are the main cause of liver fibrosis.This article mainly introduces HBV-induced liver inflammation and the interaction between innate immune cells and HSCs and briefly describes the role of monocytes/macrophages and natural killer cells in the activation and killing of HSCs and the immunomodulatory effect of HSCs in the presence of HBV.

关 键 词：乙型肝炎病毒 肝硬化 肝星状细胞 单核巨噬细胞系统 自然杀伤细胞 

分 类 号：R512.62[医药卫生—内科学]