纳米制剂在重塑肿瘤微环境和增强免疫疗效中的研究进展  

Research Progress of Nano-preparation in Remodeling Tumor Microenvironment and Enhancing Immune Efficacy

作　　者：陈少伟 应苗法[1] 顾胜龙 赵蕊[1] 李明星 CHEN Shao-wei;YING Miao-fa;GU Sheng-long;ZHAO Rui;LI Ming-xing(Department of Pharmacy,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou 310016,China;Department of Pharmacy,Xiasha Hos-pital Hangzhou,Hangzhou 310018,China)

机构地区：[1]浙江大学医学院附属邵逸夫医院药剂科,杭州310016 [2]杭州市下沙医院药剂科,杭州310018

出　　处：《中国药学杂志》2020年第2期85-89,共5页Chinese Pharmaceutical Journal

基　　金：浙江省自然科学基金项目资助(YY19H310010)。

摘　　要：肿瘤屏障以及肿瘤组织微环境的改变导致肿瘤免疫疗法的治疗受限,不良反应增多。近年来,纳米制剂在肿瘤免疫治疗过程中,对于调控免疫缺陷、改善肿瘤组织微环境、增强免疫疗效等方面取得了许多新的进展。笔者主要对影响肿瘤免疫治疗疗效的肿瘤微环境因素进行阐述,并对纳米制剂用于重塑肿瘤微环境的策略进行综述。Because of the tumor barrier and the microenvironment of tumor tissue,the treatment of tumor immunotherapy is limited and increased adverse reactions.In recent years,nano-preparation has made many new advances in the process of tumor immunotherapy for regulating immune deficiency,remodeling tumor tissue microenvironment,and enhancing the effect of immunotherapy.This article mainly describes the microenvironmental factors of affecting the efficacy of tumor immunotherapy,and reviews the strategies of nanopreparation for remodeling the tumor microenvironment.

关 键 词：纳米制剂 肿瘤微环境 重塑 免疫治疗 

分 类 号：R944[医药卫生—药剂学]