11例1型发作性睡病睡眠结构的多导睡眠图分析  

A Study of Sleep Architecture in 11 Cases of Type 1 Narcolepsy by Polysomnogram

作　　者：吴美娜[1] 林芳[1] 王小勇[1] 陈海泓 季晓林[1] 严金柱[1] WU Meina;LIN Fang;WANG Xiaoyong;CHEN Haihong;JI Xiaolin;YAN Jinzhu(Department of Neurology,Sleep Medical Center,Fujian Province Governmental Hospital,The Affiliated Hospital of Fujian Health College,Fuzhou 350003,China)

机构地区：[1]福建省级机关医院,福建卫生职业技术学院附属医院神经内科,睡眠医学中心,福州350003

出　　处：《福建医科大学学报》2020年第1期29-32,共4页Journal of Fujian Medical University

摘　　要：目的探讨1型发作性睡病夜间睡眠的结构特点。方法收集1型发作性睡病患者11例和有日间嗜睡但排除相关睡眠疾病的儿童20例。使用多导睡眠监测仪进行整夜(>7 h)连续包括16导脑电图的视频多导睡眠监测(PSG),并于次日进行5次多次小睡潜伏期试验(MSLT)。结果与对照组比较,1型发作性睡病组在入睡后觉醒时间占总卧床时间的百分比(WASO%)、非快速眼球运动(NREM)1期睡眠期比例(N1%)增加[17.60(13.10)vs 5.00(12.80),P<0.05;(19.93±12.00)vs(10.12±5.63),P<0.05],入睡潜伏期、快速眼球运动(REM)睡眠潜伏期缩短[5.50 min(11.50 min)vs 13.50 min(22.87 min),P<0.05;(93.50±106.61)min vs(157.47±65.74)min,P<0.05],NREM 3期睡眠期比例(N3%)减少[(17.50±5.60)vs(24.48±7.60),P<0.05];但睡眠效率、NREM 2期睡眠期比例(N2%)、REM睡眠期比例(R%)、醒觉指数、睡眠期周期性腿动指数、睡眠呼吸暂停/低通气指数等差别无统计学意义。结论1型发作性睡病患者存在夜间睡眠结构紊乱、睡眠片段化现象。Objective To explore the characteristics of night sleep structure in type 1 narcolepsy.Methods The enrolled subjects were:11 type 1 narcolepsy patients and 20 controls who complained of daytime sleepiness,but with no sleep related diseases.All subjects attended neurology clinic from January 2007 to December 2017.All subjects underwent overnight(>7 h)consecutive video-polysomnography(vPSG)with 16 channel electroencephalograph(EEG)and multiple sleep latency test(MSLT)including five nap opportunities in the next day.Results Compared with the control group,type 1 narcolepsy had more wake time after sleep onset(WASO)in percentage of time in bed(WASO%)and increased NREM 1 sleep period(N1)%[17.60(13.10)vs 5.00(12.80),P<0.05;(19.93±12.00)vs(10.12±5.63),P<0.05],shorter sleep latency and REM sleep latency[5.50 min(11.50 min)vs 13.50 min(22.87 min),P<0.05;(93.50±106.61)min vs(157.47±65.74)min,P<0.05],less NREM 3 sleep period(N3)%[(17.50±5.60)vs(24.48±7.60),P<0.05)].There was no significant difference in sleep efficiency,NREM 2 sleep period(N2)%,REM sleep period(R)%,awakening index,sleep periodic leg movement index,and sleep apnea hypopnea index(AHI).Conclusion There are abnormal sleep structure in night sleep and sleep fragmentation in patients with type 1 narcolepsy patients.

关 键 词：发作性睡病 睡眠 分泌素 下丘脑 

分 类 号：R338.63[医药卫生—人体生理学]