覆膜镍钛合金支架管一期修复结直肠穿孔的实验研究  

Experimental study on repair effect of laminated film nickel-titanium alloy stent tube on colorectal perforation in stageⅠ

作　　者：王纯忠[1] 沈三弟 卢峰 仇卫健 高小龙 肖慧莲[1] 谢明霞 杨茂华[1] 区栋财 刘楚天 WANG Chunzhong;SHEN Sandi;LU Feng;QIU Weijian;GAO Xiaolong;XIAO Huilian;XIE Mingxia;YANG Maohua;OU Dongcai;LIU Chutian(Department of General Surgery,Guangzhou First People′s Hospital,Guangzhou,Guangdong 510380,China;Department of General Surgery,Qingyuan People′s Hospital,Qingyuan,Guangdong 511500,China;Jiangsu Yangpu Medical Technology co.LTD,Yangzhou,Jiangsu 225109,China;Nanjing Minimally Invasive Technology co.LTD,Nanjing,Jiangsu 210061,China)

机构地区：[1]广东省广州市第一人民医院普通外科,510380 [2]广东省清远市人民医院普通外科,511500 [3]江苏阳普医疗科技有限公司,江苏扬州225109 [4]南京微创科技有限公司,南京210061

出　　处：《重庆医学》2020年第7期1063-1066,共4页Chongqing medicine

基　　金：广东省省级科技计划项目(2014A020215002);专利(ZL201020249863.X,ZL201720600825.6,ZL201720601337.7)

摘　　要：目的探讨覆膜镍钛合金支架管(LF-NTST)对一期修复结直肠穿孔的效果。方法采用西藏小型猪建立结直肠穿孔动物模型,设传统手术组及LF-NTST组,于术后第7、14、21天检测爆破压(BP),以及愈合部位组织中羟脯氨酸含量(HC)、微血管密度(MVD),评价穿孔愈合情况。结果手术后第7、14天,LF-NTST组BP、HC与传统手术组比较均明显升高,差异有统计学意义(P<0.05);手术后第21天差异无统计学意义(P>0.05)。手术后第7天,LF-NTST组MVD明显高于传统手术组;手术后第21天,LF-NTST组胶原纤维较传统手术组多。结论LF-NTST在动物实验中能体现出微创美观、安全有效地一期修复左半结直肠穿孔的效果。Objective To inverstigate the effect of laminated film nickel-titanium alloy stent tube(LF-NTST)for the surgery repair of colorectal perforation in stageⅠ.Methods The animal model of colon perforation was established in Tibetan miniature pig.Experiments were divided into the conventional surgery group and the LF-NTST group.On the 7th,14th,21th day after surgery,the blasting pressure(BP),hydroxyproline content(HC)and microvascular density(MCV)of healing tissues were detected for the evaluation of perforation healing.Results On the 7th,14th day after surgery,the levels of BP and HC in the LF-NTST group significantly increased,which were significantly different from the conventional surgery group(P<0.05),while there were no significant difference on 21th day after surgery between the two groups(P>0.05).On the 7th day after surgery,MCV in the LF-NTST group was significantly higher than that in the conventional surgery group.On the 21st day after surgery,there were more collagen fibers in the LF-NTST group than the conventional surgery group.Conclusion LF-NTST can effectively and safely repair colorectal perforation in stageⅠin animal experiment.

关 键 词：覆膜支架管 镍钛合金 肠穿孔 结肠疾病 直肠疾病 修复 

分 类 号：R656[医药卫生—外科学]