醋酸曲普瑞林治疗特发性中枢性性早熟女童疗效及对下丘脑-垂体-性腺轴激素水平的影响  

Therapeutic effect of triptorelin acetate on idiopathic central precocious puberty in girls and its effect on hormone levels of hypothalamus-pituitary-gonadal axis

作　　者：白敏[1] 韩宜姚 李珍[1] 蔡锡顶[3] 黄烈平[2] 陈飞[1] BAI Min;HAN Yiyao;LI Zhen;CAI Xiding;HUANG Lieping;CHEN Fei(Department of Pediatrics,Zhoushan Maternal and Child Health Hospital,Zhoushan,Zhejiang 316000,China;Department of Hospital,Zhoushan Maternal and Child Health Hospital,Zhoushan,Zhejiang 316000,China;Department of Children Healthcare,Zhoushan Maternal and Child Health Hospital,Zhoushan,Zhejiang 316000,China)

机构地区：[1]浙江省舟山市妇幼保健院儿科,316000 [2]浙江省舟山市妇幼保健院院部,316000 [3]浙江省舟山市妇幼保健院儿保科,316000

出　　处：《重庆医学》2020年第7期1128-1131,共4页Chongqing medicine

摘　　要：目的探讨醋酸曲普瑞林治疗特发性中枢性性早熟女童疗效及对下丘脑-垂体-性腺轴激素水平的影响。方法选取2016年1月至2018年6月在该院治疗的特发性中枢性性早熟女童62例作为研究对象,按照随机数字表法分为治疗组和对照组,每组31例。对照组采用常规治疗,治疗组在对照组基础上给予醋酸曲普瑞林治疗,治疗周期均持续1年。比较两组临床治疗效果,治疗前后血清性激素、子宫容积、卵巢容积、血睾酮变化。结果治疗组临床总有效率(90.32%)高于对照组(64.52%),差异有统计学意义(P<0.05)。治疗后,两组患儿促卵泡生成素(FSH)、血清促黄体生成素(LH)、雌激素(E2)水平均降低,且治疗组较对照组降低更明显,差异有统计学意义(P<0.05)。治疗后,两组患儿血睾酮水平降低,子宫容积、卵巢容积减小,治疗组较对照组变化更明显,差异有统计学意义(P<0.05)。结论应用醋酸曲普瑞林治疗特发性中枢性性早熟能有效控制因下丘脑-垂体-性腺轴功能亢进导致前移的生长发育及降低激素水平,推迟第二性征的出现,临床效果明显,安全性更高,值得临床推广应用。Objective To investigate the effect of triptorelin acetate on the treatment of idiopathic central precocious puberty in girls and its effect on hormone levels of hypothalamus-pituitary-gonadal axis.Methods The 62 girls with idiopathic central precocious puberty treated in this hospital from January 2016 to June 2018 were selected as the study subjects.They were divided into the treatment group and the control group according to random number table method,with 31 cases in each group.The control group was treated with routine treatment,while the treatment group was treated with triptorelin acetate on this basis.The treatment cycle lasted for 1 year.The clinical therapeutic effect and the changes of serum sex hormones,uterine volume,ovarian volume and serum testosterone were compared between the two groups before and after treatment.Results The total clinical effective rate of the treatment group(90.32%)was higher than that of the control group(64.52%)with a significant difference(P<0.05).After treatment,the levels of folliclestimulating hormone(FSH),luteinizing hormone(LH)and estradiol(E2)in both groups decreased,and the levels of treatment group were lower than those in the control group(P<0.05).After treatment,the serum testosterone level,uterine volume and ovarian volume of the two groups decreased.And the serum testosterone level,uterine volume and ovarian volume of the treatment group were lower than those of the control group(P<0.05).Conclusion In the treatment of idiopathic central precocious puberty,triptorelin acetate can effectively control the early growth and development caused by hypothalamus-pituitary-gonad axis hyperfunction,reducethe hormone levels and delay the appearance of secondary sexual characteristics.The clinical effect is remarkable and the safety is higher,which is worthy of clinical popularization and application.

关 键 词：特发性中枢性性早熟 醋酸曲普瑞林 下丘脑-垂体-性腺轴激素 治疗结果 

分 类 号：R725.8[医药卫生—儿科]