基于金@二氧化锰纳米片超级纳米粒子从比色到单颗粒光谱检测谷胱甘肽  

Glutathione Sensing:from Colorimetry to Single Particle Spectroscopy Based on Gold NP@MnO 2 Nanosheets Supraparticles

作　　者：凌云云 李莉 梁修蓉 夏云生[1] LING Yunyun;LI Li;LIANG Xiurong;XIA Yunsheng((1.Key Laboratory of Functional Molecular Solids,Ministry of Education,College of Chemistry and Materials Science,Anhui Normal University,Wuhu 241000,China;Department of Medical General Chemistry,School of Pharmacy,Wannan Medical College,Wuhu 241002,China)

机构地区：[1]安徽师范大学化学与材料科学学院,教育部功能分子固体重点实验室,芜湖241000 [2]皖南医学院药学院,医用基础化学教研室,芜湖241000

出　　处：《高等学校化学学报》2020年第4期623-632,共10页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:21775004)和皖南医学院中青年科研项目(批准号:WK201512)资助.

摘　　要：合成了由金纳米球和二氧化锰薄片组成的金@二氧化锰纳米片超级纳米粒子(AMNS-SPs),将其作为探针,利用比色和单颗粒光谱2种分析方法进行了谷胱甘肽的传感检测.该传感检测基于选择性刻蚀探针AMNS-SPs中的二氧化锰纳米片,使得该探针的局域表面等离子共振波长蓝移.实验结果表明,比色法和单颗粒光谱法检测谷胱甘肽的检出限分别为0.018μmol/L和23.2 fmol/L,且后者是目前检测谷胱甘肽灵敏度最高的传感方法之一.该传感方法的优异性能主要源于非常薄的二氧化锰纳米片.We herein study glutathione(GSH)sensing by two kinds of assay modes,namely colorimetry and single particle spectroscopy,using the as-prepared hybrid supraparticles made of gold nanoparticles and MnO 2 nanosheets(denoted as AMNS-SPs)as probes.The sensing is based on the selective etching of decorated MnO 2 nanosheets,which causes a substantial blue shift of the localized surface plasmon resonance of the AMNS-SPs.In terms of the two sensing systems,the detection limits are 0.018μmol/L and 23.2 fmol/L,respectively.To our knowledge,the latter is one of the highest sensitivity for GSH sensing.This favorable performance is attributed to a rather thin thickness of the decorated MnO 2 nanosheets.

关 键 词：谷胱甘肽 比色 裸眼检测 单颗粒光谱 

分 类 号：O657.3[理学—分析化学]