基于正电荷和光热协同效应的新型半导体聚合物纳米抗菌材料  

New Semiconducting Polymer Nanoparticles for Antibacterial Agent by the Synergetic Effect of Positive Charge and Photothermal Conversion

作　　者：潘国勇 荔雅文 马立军 马宇帆 艾文婷 王振国[1] 侯欣慧 戈里戈瑞·齐格亚诺夫 王卓 PAN Guoyong;LI Yawen;MA Lijun;MA Yufan;AI Wenting;WANG Zhenguo;HOU Xinhui;Grigory V·Zyryanov;WANG Zhuo(State Key Laboratory of Chemical Resource Engineering,Beijing Advanced Innovation Center for Soft Matter Science and Engineering,College of Chemistry,Beijing University of Chemical Technology,Beijing 100029,China;Ural Federal University Yekaterinburg 620002,Russian Federation;Postovsky Institute of Organic Synthesis,Ural Branch of the Russian Academy of Sciences,Yekaterinburg 620108,Russian Federation)

机构地区：[1]化工资源有效利用国家重点实验室,北京软物质科学与工程高精尖创新中心,北京化工大学化学学院,北京100029 [2]乌拉尔联邦大学,俄罗斯联邦叶卡捷琳堡620002 [3]普斯托夫斯基有机合成研究所,俄罗斯科学院乌拉尔分院,俄罗斯联邦叶卡捷琳堡620108

出　　处：《高等学校化学学报》2020年第4期670-681,共12页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:81961138011,21775010);北京市自然科学基金(批准号:7192106);中央高校基本科研业务费(批准号:XK1901,XK1802-6)资助.

摘　　要：由于抗生素的不当使用和细菌多药耐药的出现,迫切需要开发新的抗菌剂.本文制备了具有光热转换性能的正电荷半导体高分子材料及具有协同抗菌活性的半导体聚合物纳米粒子(SP-PPh 3 NPs).SP-PPh 3 NPs的光热转化效率为43.8%.带正电荷的SP-PPh 3 NPs可以附着在细菌上,有助于将热量有效传递给细菌.在热和正电荷的协同作用下,SP-PPh 3 NPs对革兰氏阴性大肠杆菌(\%E.coli\%)和革兰氏阳性金黄色葡萄球菌(\%S.aureus\%)均具有抗菌活性,其对二者的体外抑菌率分别为99.9%和98.6%.此外,SP-PPh 3 NPs具有良好的生物相容性,对小鼠的主要器官几乎无副作用.对细菌感染的小鼠皮肤伤口用SP-PPh 3 NPs治疗12 d后,伤口可以很好地愈合.Because of the abuse of antibiotics and the emergence of bacterial resistance,the new antibacterial agents are required urgently.Herein,we prepared semiconducting polymer nanoparticles(SP-PPh 3 NPs)with synergistic antibacterial activity due to photothermal properties and positive charge.SP-PPh 3 NPs have broad-spectrum antibacterial properties against Gram-negative Escherichia coli(E.coli)and Gram-positive Staphylococcus aureus(S.aureus).The photothermal conversion efficiency of SP-PPh 3 NPs is 43.8%.Moreover,the positive charge of SP-PPh 3 NPs can adhere to bacteria,which is helpful to transmit heat to bacteria effectively.Under the synergistic effect of heat and positive charge,the antibacterial rates of E.coli and S.aureus treated with SP-PPh 3 NPs are 99.9%and 98.6%in vitro,respectively.In addition,SP-PPh 3 NPs have good biocompatibility and have almost no side effects on the major organs of mice.The bacteria-infected skin wounds on mice can completely heal after 12 d treated with SP-PPh 3 NPs.

关 键 词：半导体聚合物 正电荷纳米颗粒 光热转换 抗菌 

分 类 号：O633[理学—高分子化学]