宫内二甲双胍暴露对子代健康的远期影响  

Long-term effects of intrauterine exposure to metformin on offspring

作　　者：刘恒言 陈畅 李斐[1] 张琳[1] 张军[1] Liu Hengyan;Chen Chang;Li Fei;Zhang Lin;Zhang Jun(Ministry of Education and Shanghai Key Laboratory of Children's Environmental Health,Xinhua Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200092,China)

机构地区：[1]上海交通大学医学院附属新华医院环境与儿童健康教育部和上海市重点实验室,200092

出　　处：《中华围产医学杂志》2020年第2期126-130,共5页Chinese Journal of Perinatal Medicine

基　　金：国家自然科学基金(81530086)。

摘　　要：二甲双胍是一种口服降糖药,现广泛应用于妊娠期糖尿病、多囊卵巢综合征和肥胖孕妇。目前研究显示,宫内二甲双胍暴露对子代的围产结局如新生儿低血糖、新生儿呼吸窘迫综合征、早产等无明显影响。考虑到二甲双胍可通过胎盘屏障,宫内二甲双胍暴露可潜在作用于胎盘和胎儿,可能会改变子代细胞代谢及影响正常激素水平等。依据健康与疾病的发育起源理论,宫内二甲双胍暴露对子代生长发育、代谢、生殖功能及神经心理发育的长期影响值得持续关注,本文对这些内容进行综述。As an oral antidiabetic drugs,metformin has been widely used to treat various diseases such as gestational diabetes mellitus,polycystic ovary syndrome and obesity in pregnant women.Current literature suggests that intrauterine metformin exposure has no significant impact on perinatal outcomes of the offspring,such as neonatal hypoglycemia,neonatal respiratory distress syndrome,premature delivery and others.However,considering the possible transfer of metformin across the placental barrier,intrauterine metformin exposure may potentially influence the development of placenta and the fetus,cell metabolism,and hormone levels.According to the"Developmental Origins of Health and Diseases"theory,the long-term effect of intrauterine metformin exposure on the growth,metabolism,reproductive function and neuropsychological development of offspring reviewed here still need continuous attention.

关 键 词：二甲双胍 产前暴露迟发效应 生长和发育 儿童发育 

分 类 号：R714[医药卫生—妇产科学]