铁氰化锰纳米对比剂对大鼠肝脏MRI T1WI增强扫描效果的实验研究  

Experimental study on enhancement effect of manganese ferrocyanide nano-contrast agent on T1WI of rat liver MRI

作　　者：潘冬梅 范国华[2] 王月训[1] Pan Dongmei;Fan Guohua;Wang Yuexun(不详;Department of Radiology,Second Affiliated Hospital of Suzhou University,Suzhou 215004,China)

机构地区：[1]山东省济宁市第一人民医院放射科,山东济宁272000 [2]苏州大学附属第二医院放射科,江苏苏州215004

出　　处：《中国中西医结合影像学杂志》2020年第2期201-204,共4页Chinese Imaging Journal of Integrated Traditional and Western Medicine

摘　　要：目的:探讨铁氰化锰纳米对比剂对大鼠肝脏的MRI T1WI增强扫描效果。方法:通过透射电子显微镜、X线衍射分析仪对铁氰化锰纳米对比剂结构、粒径分布进行观察。取健康雄性SD大鼠6只,分别于注入对比剂前后不同时间点对大鼠肝脏行MRI T_1WI序列扫描,绘制肝脏SNR-时间动态变化曲线。采用单因素方差分析比较增强扫描前后各时间点肝脏SNR差异。结果:铁氰化锰纳米粒子粒径1~5 nm,分散均匀。注射对比剂后5 min,大鼠肝脏明显强化,20 min达到峰值,4 h开始明显下降。注射对比剂后5 min^6 h各时间点肝脏SNR与平扫相比,差异均有统计学意义(均P<0.05);10 h^7 d各时间点肝脏SNR与平扫相比,差异均无统计学意义(均P>0.05);24 h后肝脏信号强度恢复至平扫水平。结论:铁氰化锰纳米对比剂对大鼠肝脏具有明显的强化效果,且持续时间较长,具有作为肝脏MRI对比剂的潜能。Objective:To investigate the enhancement effect of manganese ferricyanide nanoparticles on T1WI of rat liver MRI.Methods:The structure and particle size distribution of manganese ferricyanide nano-contrast agent were observed by transmission electron microscopy(TEM)and X-ray diffraction(XRD).Six healthy male SD rats were scanned by magnetic resonance T1WI sequence at different time points before and after injection of contrast medium.SNR-time dynamic curve were drawn.SI,SNR of liver were compared between enhancement at each time point and unenhanced respectively using one-way analysis of variance.Results:The size of manganese ferricyanide nanoparticles was about 1~5 nm,and the dispersion was uniform.The liver of rat was significantly enhanced at 5 min after injecting manganese hexacyanoferrate nanoparticles contrast agent,and enhancement of liver reached the peak at 20 min,then it began to decrease obviously at 4 h.Comparing SNR of liver at each time point of 5 min^6 h after injection with SNR of liver unenhanced,the differences were statistically significant(P<0.05).There were no significant differences(P>0.05)of SNR of liver between 10 h^7 d each time point and unenhanced.The signal intensity of liver recovered to unenhanced level after 24 h.Conclusions:Manganese hexacyanoferrate nano particle contrast agents have significantly enhanced effect in the liver,having longer duration,which has potential as a contrast agent for liver magnetic resonance imaging.

关 键 词：磁共振成像 锰化合物 肝 造影剂 大鼠 

分 类 号：R445.2[医药卫生—影像医学与核医学]