74例新型冠状病毒肺炎临床特征分析  

Clinical characteristics of 74 hospitalized patients with COVID-19

作　　者：张维[1] 侯维[1] 李侗曾[2] 李爱新 潘闻[4] 金荣华[5] 梁连春[2] 胡中杰[1] Zhang Wei;Hou Wei;Li Tongzeng;Li Aixin;Pan Wen;Jin Ronghua;Liang Lianchun;Hu Zhongjie(Department of Critical Care Medicine of Liver Disease, Beijing Youan Hospital, Capital Medical University, Beijing 100069,China;Department of Infectious Diseases,Beijing Youan Hospital,Capital Medical University,Beijing 100069,China;Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing 100069,China;Department of Emergency,Beijing Youan Hospital,Capital Medical University,Beijing 100069,China;Beijing Youan Hospital,Capital Medical University,Beijing 100069,China)

机构地区：[1]首都医科大学附属北京佑安医院肝病重症医学科,北京100069 [2]首都医科大学附属北京佑安医院感染综合科,北京100069 [3]首都医科大学附属北京佑安医院感染中心,北京100069 [4]首都医科大学附属北京佑安医院急诊科,北京100069 [5]首都医科大学附属北京佑安医院,北京100069

出　　处：《首都医科大学学报》2020年第2期161-167,共7页Journal of Capital Medical University

摘　　要：目的描述首都医科大学附属北京佑安医院收治的74例确诊新型冠状病毒肺炎(COVID-19)患者的流行病学和临床特征。方法单中心、回顾性分析首都医科大学附属北京佑安医院74例确诊为COVID-19的连续住院患者,入组时间为2020年1月21日至2月11日,最终随访日期为2020年2月17日。收集并分析流行病学、人口学、临床、实验室、放射学、治疗和转归的数据。结果74名COVID-19住院患者平均年龄为(52.7±19.1)岁,男性35例,女性39例。从出现症状到确诊平均时间为(5.1±2.8)d。有湖北疫区旅居史者39例(47.3%)、聚集性发病患者48例(64.9%)。常见症状包括发热67例(90.5%)、干咳20例(27%)。42例(56.8%)患者观察到淋巴细胞减少,35例(47.3%)患者观察到白细胞减少。放射学表现为单侧或双侧的斑片状阴影或磨玻璃样阴影。在所有74例患者中,并发急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)患者7例(9.5%),并发休克患者5例(6.8%),入住重症监护室11例(14.9%),治愈出院患者55例(74.3%),平均住院时间为(12.3±4.4)d。结论COVID-19呈聚集性发病,少数患者可进展为急性呼吸窘迫综合征。高龄和基础病可能是预后不良的危险因素。Objective To describe the epidemiological and clinical characteristics of 74 patients diagnosed with COVID-19 in our hospital.Methods A retrospective,single-center case series analysis included 74 consecutive hospitalized patients with confirmed COVID-19 at Beijing Youan Hospital,Capital Medical University,from January 21 to February 11,2020.The final date of follow-up was February 17,2020.The data of epidemiology,demographics,clinic,laboratory test,radiological examination,treatment,and complications were collected and analyzed.Outcomes of critically ill patients and noncritically ill patients were compared.Results Of 74 patients with COVID-19,the average age was(52.7±19.1)years,the minimum age 1 year old and the maximum age 94 years old.Thirty five were male.According to the severity of the disease at the time of admission,there were 56 cases of common type,9 cases of severe type and 9 cases of critical severe type.The average time from onset of symptoms to diagnosis was(5.1±2.8)days.There were 39 cases(47.3%)who had lived in the epidemic area of Hubei Province,48 cases(64.9%)who had clustered onset.The common symptoms included fever 67(90.5%),dry cough 20(27%)and dyspnea 17(23.0%).The average time from first symptom to acute respiratory distress syndrome(ARDS)was(9.3±3.8)days,and to Intensive Care Unit(ICU)admission was(10.5±4.7)days.Forty two patients(56.8%)had lymphocytopenia and 35 patients(47.3%)had leukopenia.Twenty seven patients(36.5%)had elevated alanine aminotransferase,7 patients(9.5%)had elevated creatine kinase;12 patients(16.2%)had elevated myoglobin.Compared with the common patients,the lymphocyte decreased more significantly in the severe and critical severe patients.The chest computed tomographic scans showed bilateral patchy shadows or ground glass opacity in the lungs of all patients.Among all the 74 patients,23(31.1%),17(23%),2(2.7%)and 6(8.1%)received low flow oxygen inhalation,high flow oxygen inhalation,non-invasive positive pressure ventilation and invasive positive pressure ventilat

关 键 词：冠状病毒 新型冠状病毒肺炎 流行病学 临床特征 

分 类 号：R563.1[医药卫生—呼吸系统]