医用导管抗菌表面的构建及研究进展  

Construction of Antibacterial Catheter Surface and Its Recent Advances

作　　者：于欢 石恒冲[1] 李学[2] 栾世方[1,3] YU Huan;SHI Hengchong;LI Xue;LUAN Shifang(State Key Laboratory of Polymer Physics and Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China;School of Chemistry and Chemical Engineering,University of Jinan,Jinan 250022,China;National Engineering Laboratory for Medical Implantable Devices,Weigao Group Co.,Ltd.,Weihai 264209,China)

机构地区：[1]中国科学院长春应用化学研究所高分子国家重点实验室,吉林长春130022 [2]济南大学化学化工学院,山东济南250022 [3]威高集团有限公司医用植入器械国家工程实验室,山东威海264209

出　　处：《青岛科技大学学报（自然科学版）》2020年第2期21-28,34,共9页Journal of Qingdao University of Science and Technology:Natural Science Edition

基　　金：国家重点研发计划项目(2017YFC1104800);中科院威高计划项目(2016YFC1100402);中科院青年创新促进会基金项目(2017269).

摘　　要：植/介入类医用导管相关感染是植入手术中最严重的并发症之一,它们不仅具有高发病率和死亡率,而且还可能潜在威胁着患者及医护人员的生命安全.细菌在医用导管表面的定植及后期生物膜的生成通常是引起感染的罪魁祸首,因此,如何有效的阻止细菌定植及生物膜的形成已成为全球相关领域面临的严峻问题.综述了近年来医用导管相关感染的现状及在生物医用导管上构建抗菌表面以防止植/介入类导管相关感染的研究进展.The indwelling catheter related infections are one of the most serious complications in implant surgery which not only increase the morbidity and mortality of patients,but also potentially threaten the lives of patients and medical staffs.However,bacterial colonization on the surface of medical catheters and subsequent biofilm formation are usually the main causes of infection.Therefore,how to effectively prevent bacterial colonization and surface biofilm formation has become a serious problem in the global related field.This article reviewed the current status of medical catheter-related infections in recent years and recent strategies to prevent catheter-related infections.

关 键 词：植/介入类医用导管的相关感染 抗菌导管 生物膜 抗菌策略 

分 类 号：TH131.9[机械工程—机械制造及自动化]