四川省美沙酮维持治疗门诊首次入组患者HCV感染状况的研究  

Current Situation of HCV Infection in Newly Enrolled Patients of Methadone Maintenance Treatment Clinics in Sichuan Province

作　　者：龚毅[1] 黄惋莉[1] 李恬[1] 曾亚莉[1] 喻航[1] 赖文红[1] 刘伦皓[1] GONG Yi;HUANG Wanli;LI Tian;ZENG Yali;YU Hang;LAI Wenhong;LIU Lunhao(Sichuan Center for Disease Control and Prevention,Chengdu 610041,Sichuan Province,China)

机构地区：[1]四川省疾病预防控制中心,成都610041

出　　处：《预防医学情报杂志》2020年第3期332-336,340,共6页Journal of Preventive Medicine Information

摘　　要：目的分析美沙酮维持治疗门诊新入组患者的丙肝病毒(HCV)感染情况及影响因素,为美沙酮维持治疗门诊丙肝干预工作提供依据。方法整理2004-2017年间四川省49个美沙酮维持治疗门诊新入组患者的人口学特征、HCV感染情况等基本信息,分析不同特征患者HCV感染率的差异。结果调查对象,52.0%的人有HCV感染,2005年新入组患者HCV感染率最高(72.6%),2013年最低(41.9%)。HCV感染率在2005年后有逐渐下降趋势,2014年后趋于平稳状态。逻辑回归结果显示,女性、年龄20~49岁、文化程度为初中、居住凉山以外地区、静脉注射吸毒、共用针具者是HCV感染的危险因素。新入组患者数量从2011年起呈逐年下降趋势。结论四川省美沙酮维持治疗新入组患者的HCV感染率总体呈下降趋势,尤其凉山州地区下降明显,工作有一定成效,但凉山州以外的地区仍需加强干预;美沙酮维持治疗新入组患者数量呈下降情况,应采取策略充分发挥美沙酮门诊的干预平台作用,减少门诊治疗人员HCV感染。Objective To analyze the status and influencing factors of hepatitis c virus(HCV) infection among newly enrolled patients in the methadone maintenance treatment(MMT) clinics, so as to provide a basis for the intervention of HCV in the MMT clinics. Methods Demographic characteristic, HCV infection status and other basic information of newly enrolled patients in 49 MMT clinics in Sichuan province from 2004 to 2017 were analyzed. Results A total of 36 334 patients was surveyed, and 52.0% of the patients were infected with HCV. The rate of HCV infection was the highest in 2005(72.6%) but the lowest in 2013(41.9%). After 2005,the rate of HCV infection decreased gradually. After 2014, the rate of HCV infection kept in a relatively stable state. Logistic regression models showed that women, 20-49 years old, junior high school education, living outside of Liangshan, intravenous drug use and needle sharing were risk factors of HCV infection. There was a decreasing trend of the number of patients attending MMT since2011. Conclusion The rate of HCV infection of patients in MMT showed an declining trend in Sichuan province,especially in Liangshan prefecture,which indicates that the prevention work had certain effects. However, the prevention still needs to be strengthened in places outside of Liangshan. The number of newly enrolled patients in MMT clinics has been decreasing in recent years. Measures should be taken to strengthen the role of MMT as an intervention platform and reduce the HCV infection rate in the drug users.

关 键 词：美沙酮维持治疗 丙肝 感染率 

分 类 号：R512.63[医药卫生—内科学]